Scientists glue two proteins together, driving cancer cells to self-destruct
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Updates every hour. Last Updated: 4-May-2025 19:09 ET (4-May-2025 23:09 GMT/UTC)
On November 27, the prestigious journal Nature will publish the results of an innovative breast cancer research project from the Netherlands. This study, the SONIA trial, showed that delaying and shortening the duration of a specific anti-cancer therapy (CDK4/6 inhibitors) in patients with hormone receptor-positive advanced breast cancer leads to similar survival outcomes, while reducing toxicity and achieving substantial cost reductions: over 45 million euros per year in the Netherlands and over 5 billion dollars in the United States.
A University of Toronto study is providing reassuring evidence about the consumption of soy foods in women* who are postmenopausal. The analysis of 40 randomized controlled trials in over 3,000 participants found that estrogen-like compounds in soy had no effect on key markers of estrogen-related cancers, supporting its safety as both a food and potential therapy.
In a new research paper published in MedComm-Oncology, the team of Yongsheng Li/Dairong Li/Huakan Zhao provided an effective and accurate ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) tool for the simultaneous detection of aumolertinib, osimertinib, gefitinib and their major metabolites, demonstrating the great bioavailability and tissue distribution characteristics of aumolertinib.
Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1. MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear. Published in PNAS, researchers at the Monash University Biomedicine Discovery Institute in Australia have identified a form of Vitamin B6 bound to MR1 as a means of engaging tumour-reactive immune cells.