FOXP4 gene identified in the first large-scale genetic study on Long COVID with participation of the GCAT
Peer-Reviewed Publication
Updates every hour. Last Updated: 18-Jun-2025 13:10 ET (18-Jun-2025 17:10 GMT/UTC)
An international team of researchers has found a genetic link to long-term symptoms after COVID-19. The identified gene variant is located close to the FOXP4 gene, which is known to affect lung function. The study, published in Nature Genetics, was led by researchers at Karolinska Institutet in Sweden and the Institute for Molecular Medicine Finland.
The rapid evolution of SARS-CoV-2 variants during the COVID-19 pandemic emphasized the need for advanced tools to predict future outbreaks. The study introduces CoVFit, an AI-driven model that analyzes spike protein mutations to assess the fitness of SARS-CoV-2 variants. By combining molecular and epidemiological data, CoVFit provides early insights into the transmissibility and immunity evasion of emerging variants, offering a powerful tool for pandemic preparedness, vaccine design, and global risk assessment.
Hydrogen boride (HB) nanosheets can inactivate viruses, bacteria, and fungi within minutes in the dark conditions. By coating surfaces with HB nanosheets, it rapidly inactivates SARS-CoV-2, influenza virus, and other pathogens. The nanosheets work by denaturing microbial proteins, offering a safe, effective, and versatile antimicrobial coating for everyday items.
Since the COVID-19 pandemic, there has been a decline in U.S. vaccine uptake, while widespread misinformation and distrust make it challenging to craft effective public health responses. In a new paper, University of Illinois Urbana-Champaign researchers discuss three case studies exemplifying different vaccine attitudes and behaviors. Their findings underscore the need for flexible approaches to reach diverse audiences with disease prevention strategies.
A St. Jude-led collaboration characterized the unique features of hospitalized infants’ immune response to SARS-CoV-2, the virus that causes COVID-19. Findings show that the immune response looked different in these infants compared to other ages, including increases in the antiviral interferon protein and interferon-stimulated genes in most immune cells, paired with high levels of inflammatory cytokines in their blood.
Researchers surveyed 4,177 adult American citizens in the United States. Participants provided opinions about four scenarios that featured individuals with distinct life circumstances and names that were racially/ethnically identifiable. The individual in the first scenario had “a genetic condition that destroyed his kidneys” and necessitated a kidney transplant. The second had “worked in a coal mine all his life” and needed a lung transplant because of black lung disease. The third was “very ill with COVID-19,” had not been vaccinated against COVID-19 and needed a lung transplant. And the fourth had alcohol use disorder and needed a liver transplant.