A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 as a potential synthetic lethal marker for enhancing the efficacy of ATM inhibitors in pancreatic cancer treatment. This innovative research provides a groundbreaking approach to targeting a tumor suppressor gene, BEND4, which is frequently methylated and silenced in pancreatic cancer. The study delves into the role of BEND4 in DNA damage repair and its potential as a therapeutic marker when combined with ATM inhibitor treatment.

Hong Kong’s unique marine environment, with its rich ecosystems, provides vital habitats and food sources for various marine species. However, rapid urbanisation and population growth pose significant challenges, including marine pollution, overfishing and climate change. A research team from the Department of Food Science and Nutrition (FSN) at The Hong Kong Polytechnic University (PolyU) is actively addressing these sustainability challenges. Their focus is on innovative marine pollution monitoring technologies and sustainable seafood research, which includes assessing the impacts of microplastics on marine ecosystems and human health, and restoring pearl oyster reefs, in alignment with the United Nations Sustainable Development Goals 2, 3 and 14.

BGI Genomics and partners have published a transformative study in Nature Communications that links genetic differences in GISTs to tailored treatment strategies. The discovery of YLPM1 as a tumor suppressor gene marks a significant step in precision oncology.

An advanced aqueous battery design incorporating photothermal technology enables rapid self-heating, making it well-suited for low-temperature environments. The battery uses photothermal current collectors to convert sunlight into heat, which is efficiently distributed throughout the system by high-conductivity suspension electrodes. This design mitigates common cold-climate challenges such as electrolyte freezing and slow ion transfer, ensuring stable performance in sub-zero conditions.

    This paper reviews the thermal design of SiC power modules for EV motor drives, focusing on optimizing irregular Pinfin structures to enhance heat dissipation. It proposes a collaborative thermal design approach involving DC bus capacitors and motors, aiming to improve overall heat management and support the development of high power density motor drives.

Two English journals hosted by the Institute of Atmospheric Physics at the Chinese Academy of Sciences (CAS), were recently acknowledged for their impact in global media.

Researchers at HIT classified the main FW control strategies of PMSMs into calculation-based methods, voltage closed-loop control methods, and model predictive control-related methods. The existing strategies are compared using various performance indicators. The advantages and disadvantages of various strategies are analyzed for different applications.

In this paper, we consider the scenario where the prover of zk-SNARK delegates its proving power to other parties.

In the quest to enhance the efficacy of chimeric antigen receptor T (CAR-T) cell therapy against hepatocellular carcinoma (HCC), a recent study has identified a pivotal role for CD39 expression in modulating the function of CAR-T cells. The research, conducted by a team of scientists, investigated the impact of CD39 modulation on CAR-T cells, hypothesizing that optimal levels of CD39 could boost the therapeutic potential of these cells against HCC. The study utilized a combination of in vitro and in vivo experiments, including the use of a subcutaneous HCC mouse model, to demonstrate that CAR-T cells with moderate CD39 expression levels displayed superior antitumor activity compared to those with high or low CD39 levels. Furthermore, the study explored the use of mdivi-1, a small molecule inhibitor, to modulate CD39 expression, revealing a synergistic effect when combined with CD39 knockdown that significantly enhanced the antitumor response.