Single-cell analyses reveal impaired type B spermatogonia differentiation and meiotic entry in C-Nap1-null testes
Peer-Reviewed Publication
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In this study, the impact of C-Nap1 on spermatogenesis using C-Nap1 knockout mouse models was investigated. Single-cell RNA sequencing of 10-day testes from wild-type and knockout mice was performed.
This study proposes a novel measurement method based on the digital image correlation (DIC) technique for determining the natural frequencies and mode shapes of prestressed concrete wind turbine towers. The results show that the DIC method is an effective, convenient, and safe approach for measuring the natural frequencies of wind turbine towers, with significant practical value.
Solid-state batteries represent the next frontier in energy storage technology, promising higher energy density and enhanced safety than conventional lithium-ion batteries. However, a persistent challenge has hindered their commercialization: the unstable interface between lithium metal anodes and solid electrolytes. Researchers have now developed an innovative solution using a LixAg alloy that could finally unlock the full potential of all-solid-state lithium metal batteries (ASSLMBs).
Electric vehicles (EVs) have emerged as a cornerstone of sustainable transportation, but their widespread adoption faces a critical safety challenge: lithium plating in lithium-ion batteries (LIBs). Lithium plating occurs when lithium ions accumulate on the surface of a battery's negative electrode rather than intercalating properly into the graphite structure. This phenomenon typically happens during fast charging, at low temperatures, or at high states of charge, which can lead to rapid capacity degradation and even catastrophic safety incidents. Traditional detection methods either require specialized equipment or lack sufficient accuracy for real-world applications. Researchers from University of Shanghai for Science and Technology have now developed a feasible solution that could optimize EV battery safety monitoring.
Prototheca wickerhamii (P. wickerhamii), an opportunistic pathogen affecting both humans and animals, is widely distributed in the environment, including soil, mud, and water sources such as rivers. However, human infections caused by this genus are rare. Unfortunately, due to the nonspecific clinical manifestations and limited awareness among clinicians, protothecosis is often underestimated and misdiagnosed. P. wickerhamii has been shown to exhibit low cytotoxicity to macrophages, potentially allowing it to evade immune clearance. Currently, the high-quality genome offers insights into the evolution and pathogenicity of Prototheca, while also serving as a genomic resource for improved diagnosis. In this study, we combined traditional culturing methods with microbiome sequencing techniques to gain a more comprehensive understanding of the microbial diversity in infected skin.
This study conducts a comparative analysis of the standard-sample-bracketing (SSB) method and the double-spike (DS) method, aiming to provide practical recommendations to researchers for selecting optimal analytical approaches for natural samples. The DS method shows greater potential to reveal subtle Mg isotope fractionations in processes such as equilibrium inter-mineral Mg isotope fractionation, partial melting of magma, and the possible fractionation during crystallization differentiation. Continuous optimization efforts will further improve the versatility and accuracy of the DS method, particularly through expanding its application scope to incorporate more diverse standard samples. Such expansion is critical for thoroughly investigating the fundamental causes of analytical discrepancies between DS and SSB methods in Mg isotope studies.
In a paper published in National Science Review, a research team from Peking University presents new insights into magnetic field sensing. The study investigates the limits of quantum magnetometers and explores criteria for determining whether a magnetometer is essentially quantum.
Colorectal cancer (CRC) is a globally prevalent malignancy with high morbidity and mortality rates, closely linked to aberrant epigenetic modifications. Among these, pseudouridine (Ψ), one of the most abundant RNA chemical modifications, plays a pivotal role in tumorigenesis by regulating mRNA stability, translation efficiency, and splicing processes. Recent studies have demonstrated that the small-molecule inhibitor Pyrazofurin, targeting the pseudouridine synthase DKC1, exhibits significant anti-tumor activity, suggesting Ψ modification as a promising therapeutic strategy for CRC. However, the dynamic changes and clinical implications of transcriptome-wide Ψ modifications in CRC remain poorly understood.
In an original research article published in MedComm - Oncology, an antiallergic drug fexofenadine was identified as a new Met inhibitory agent by a computational drug repurposing tool called “DRAR-CPI” via chemical-protein interactome analysis of known Met inhibitors. Fexofenadine was shown to overcome osimertinib resistance in non-small cell lung cancer by inhibiting Met in vitro and in vivo.