Glycosylphosphatidylinositol (GPI) anchoring for cell wall integrity and immune evasion
Peer-Reviewed Publication
Updates every hour. Last Updated: 14-Dec-2025 18:11 ET (14-Dec-2025 23:11 GMT/UTC)
GPI anchoring is indispensable for cell-wall integrity and full virulence of the maize pathogen Cochliobolus heterostrophus. Deletion of ChGPI7 or ChFEM1 crippled appressorium formation, exposes chitin, and triggers host immune detection. A total of 124 potential GPI-anchored proteins were predicted, indicating that this pathway may serve as a potential antifungal target.
Functionalized single-walled carbon nanotubes (SWCNTs) effectively delivered the amh/amhy plasmid into all-female mandarin fish via immersion. At 40 mg/L, plasmid DNA and transcripts were detected in gonads within 7-14 days. By 60-120 days, some fish developed masculinized gonads with downregulated foxl2/cyp19a1a and upregulated amh/dmrt1. The study demonstrates SWCNTs as a viable gene delivery tool in fish and confirms the crucial role of amh/amhy in sex determination via the amhrII/smads pathway activating dmrt1.
Researchers at the University of Windsor developed SH17, a large open-source dataset with 8,099 images and 75,994 labeled instances to improve detection of personal protective equipment (PPE) in manufacturing. Using advanced AI models like YOLOv9, the study achieved over 70% accuracy, offering industries a scalable tool to enhance worker safety and compliance.
A research team from Fudan University has developed a hydrogel technology based on microenvironment-responsive mechanisms. The material can sense pH changes in the wound environment and dynamically release functional agents, enabling a switch from antibacterial action to tissue repair. Constructed from an interpenetrating network of sodium alginate and carboxymethyl chitosan, and loaded with tannic acid and zinc-doped bioactive glass, the hydrogel rapidly releases antibacterial molecules during infection and gradually delivers regenerative ions during healing—achieving, for the first time, precise, stage-specific control of infected wound treatment.
Glycolipid metabolic disorders, linked to cardiovascular diseases and cancer, are a major global health challenge. Current single-disease treatments remain unsatisfied in reducing long-term risks. In 2024, Professor Jiao Guo along with global experts launched the "Global Initiative for Glycolipid Metabolic Health" to enhance prevention through scientific research, public education, and integrated management systems.
Reactive planning and control capacity for collaborative robots is essential when the tasks change online in an unstructured environment. This is more difficult for collaborative mobile manipulators (CMM) due to high redundancies. To this end, this paper proposed a reactive whole-body locomotion-integrated manipulation approach based on combined learning and optimization. First, human demonstrations are collected, where the wrist and pelvis movements are treated as whole-body trajectories, mapping to the end-effector (EE) and the mobile base (MB) of CMM, respectively. A time-input kernelized movement primitive (T-KMP) learns the whole-body trajectory, and a multi-dimensional kernelized movement primitive (M-KMP) learns the spatial relationship between the MB and EE pose. According to task changes, the T-KMP adapts the learned trajectories online by inserting the new desired point predicted by M-KMP. Then, the updated reference trajectories are sent to a hierarchical quadratic programming (HQP) controller, where the EE and the MB trajectories tracking are set as the first and second priority tasks, generating the feasible and optimal joint level commands. An ablation simulation experiment with CMM of the HQP is conducted to show the necessity of MB trajectory tracking in mimicking human whole-body motion behavior. Finally, the tasks of the reactive pick-and-place and reactive reaching were undertaken, where the target object was randomly moved, even out of the region of demonstrations. The results showed that the proposed approach can successfully transfer and adapt the human whole-body loco-manipulation skills to CMM online with task changes.
Embodied learning for object-centric robotic manipulation is a rapidly developing and challenging area in embodied AI. It is crucial for advancing next-generation intelligent robots and has garnered significant interest recently. Unlike data-driven machine learning methods, embodied learning focuses on robot learning through physical interaction with the environment and perceptual feedback, making it especially suitable for robotic manipulation. In this paper, researchers provide a comprehensive survey of the latest advancements in this field and categorize the existing work into three main branches: 1) Embodied perceptual learning, which aims to predict object pose and affordance through various data representations; 2) Embodied policy learning, which focuses on generating optimal robotic decisions using methods such as reinforcement learning and imitation learning; 3) Embodied task-oriented learning, designed to optimize the robot′s performance based on the characteristics of different tasks in object grasping and manipulation. In addition, researchers offer an overview and discussion of public datasets, evaluation metrics, representative applications, current challenges, and potential future research directions. A project associated with this survey has been established at https://github.com/RayYoh/OCRM_survey.
This work establishes the first asymptotic stability result for multi-wave patterns in damped wave equations with partially linearly degenerate flux. The authors prove that global solutions converge to a composite wave—combining a rarefaction wave and a viscous contact wave— without smallness assumptions on initial data or wave strength. To address the loss of uniform convexity, the study introduces three novel techniques: (i) a refined construction of the viscous contact wave accounting for non-normalizable propagation speed, (ii) a reformulation through the Jin–Xin relaxation system to establish uniform boundedness, (iii) a domain-partitioned weighted energy estimate to handle flux degeneracy. These methods provide a complete description of the large-time behavior of the damped wave equation with partially linearly degenerate flux and offer new analytical tools for problems involving nonconvex fluxes.