A recent study has unveiled the pivotal role of Ferroptosis Suppressor Protein 1 (FSP1) in intervertebral disc degeneration (IDD), a primary cause of chronic lower back pain.

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of hypospadias, a common congenital malformation affecting male urethral development.

We conceptualize bioresource upgrade for sustainable energy, environment, and biomedicine with a focus on circular economy, sustainability, and carbon neutrality using high availability and low utilization biomass (HALUB). We acme energy-efficient technologies for sustainable energy and material recovery and applications. The technologies of thermochemical conversion (TC), biochemical conversion (BC), electrochemical conversion (EC), and photochemical conversion (PTC) are summarized for HALUB. Microalgal biomass could contribute to a biofuel HHV of 35.72 MJ Kg⁻¹ and total benefit of 749 $/ton biomass via TC. Specific surface area of biochar reached 3000 m² g⁻¹ via pyrolytic carbonization of waste bean dregs. Lignocellulosic biomass can be effectively converted into bio-stimulants and biofertilizers via BC with a high conversion efficiency of more than 90%. Besides, lignocellulosic biomass can contribute to a current density of 672 mA m⁻² via EC. Bioresource can be 100% selectively synthesized via electrocatalysis through EC and PTC. Machine learning, techno-economic analysis, and life cycle analysis are essential to various upgrading approaches of HALUB. Sustainable biomaterials, sustainable living materials and technologies for biomedical and multifunctional applications like nano-catalysis, microfluidic and micro/nanomotors beyond are also highlighted. New techniques and systems for the complete conversion and utilization of HALUB for new energy and materials are further discussed.

The seawater desalination based on solar-driven interfacial evaporation has emerged as a promising technique to alleviate the global crisis on freshwater shortage. However, achieving high desalination performance on actual, oil-contaminated seawater remains a critical challenge, because the transport channels and evaporation interfaces of the current solar evaporators are easily blocked by the oil slicks, resulting in undermined evaporation rate and conversion efficiency. Herein, we propose a facile strategy for fabricating a modularized solar evaporator based on flexible MXene aerogels with arbitrarily tunable, highly ordered cellular/lamellar pore structures for high-efficiency oil interception and desalination. The core design is the creation of 1D fibrous MXenes with sufficiently large aspect ratios, whose superior flexibility and plentiful link forms lay the basis for controllable 3D assembly into more complicated pore structures. The cellular pore structure is responsible for effective contaminants rejection due to the multi-sieving effect achieved by the omnipresent, isotropic wall apertures together with underwater superhydrophobicity, while the lamellar pore structure is favorable for rapid evaporation due to the presence of continuous, large-area evaporation channels. The modularized solar evaporator delivers the best evaporation rate (1.48 kg m⁻² h⁻¹) and conversion efficiency (92.08%) among all MXene-based desalination materials on oil-contaminated seawater.

This work exemplifies the transformative potential of integrating numerical simulations with field data. The findings not only resolve regional tectonic controversies but also establish a methodology applicable to analogous systems worldwide, reinforcing the importance of interdisciplinary approaches in decoding Earth’s complex architectures.

We have developed a dual bio-/photo-catalytic system for achieving enantioselective hydroamination of enamines, which can provide easy access to chiral vicinal diamines. These reactions proceed efficiently under green light excitation and exhibit excellent enantioselectivities (up to 99% enantiomeric excess).We have developed a dual bio-/photo-catalytic system for achieving enantioselective hydroamination of enamines, which can provide easy access to chiral vicinal diamines. These reactions proceed efficiently under green light excitation and exhibit excellent enantioselectivities (up to 99% enantiomeric excess).

A groundbreaking study introduces a novel Transformer-based time-series framework designed to predict daily risk alerts for sepsis patients in the Intensive Care Unit (ICU). This model, leveraging sequential data from the eICU database, dynamically captures evolving health trajectories, enabling real-time identification of high-risk patients and actionable insights for personalized interventions. The study, titled “Predictive model for daily risk alerts in sepsis patients in the ICU: visualization and clinical analysis of risk indicators” published in Precision Clinical Medicine February 8, 2025, demonstrates exceptional predictive power, with an AUC increasing from 0.87 on admission day to 0.92 by day 5, offering a new paradigm for ICU prognostics.

This study shows that the SAAR diet regulates glucose and lipid metabolism to support weight control without impacting appetite or physical activity (Figure 1), offering new insights into obesity management. The potential benefits and risks of a low-SAA diet in humans require further research to validate its molecular mechanisms and assess its clinical applications.

This research not only brings new hope for sustainable agricultural production but also lays a strong scientific foundation for future ecosystem service management. The complexity of soil micro-food webs and their impact on soil fertility is undoubtedly a crucial topic for future agricultural research and practice. Media and the public should pay attention to these findings, as they have the potential to revolutionize agricultural practices and address the dual challenges of food security and environmental protection.