The way a drug works and what it targets in the body are key factors in how effectively it can kill harmful cells. This work looks at a group of important proteins called receptor tyrosine kinases, which are often involved in diseases like cancer. Scientists have found that certain chemical structures—called heterocycles, such as pyrimidine, thiazole, imidazole, indole, acridone, and triazine—can be used to make drugs that target these proteins. With some changes, these compounds could also be designed to affect other disease pathways in the future.

The metal-supported reversible protonic ceramic cell (MS-rPCC) combines the dual advantages of metal support and proton conduction, enabling efficient low-temperature operation, high mechanical strength, and exceptional thermal cycling stability. However, a critical challenge in MS-rPCC fabrication lies in element diffusion from the metal support and the thermal expansion mismatch between the metallic and ceramic phases. To address this issue, a pure nickel metal support and a newly developed transition layer (80 wt.% NiO–20 wt.% BaZr0.1Ce0.7Y0.2O3-δ, BZCY) were employed to mitigate thermal expansion mismatch, thereby enhancing the performance and stability of the MS-rPCC. This work presents a novel approach to facilitate the commercialization and widespread application of MS-rPCC technology.

In this April 2025 issue of Translational Lung Cancer Research, a pioneering study, led by Professor Shuben Li from the First Affiliated Hospital of Guangzhou Medical University, revisits a classic but unresolved question in airway surgery: Should tracheobronchial anastomoses be routinely wrapped following resection and reconstruction?

The article, titled "Tracheobronchial resection and reconstruction: to wrap or not to wrap the anastomosis?"，presents a single-center experience to explore the relationship between wrapping the anastomosis after airway reconstruction and short-term surgical outcomes, and to investigate whether wrapping the anastomosis can reduce the incidence of postoperative adverse events.