Researchers explored Mendelian randomization to identify novel drug targets for metabolic dysfunction-associated steatotic liver disease (MASLD). This approach could revolutionize therapies for a condition affecting over one-third of adults globally.

Spatial-Temporal Forecasting, as an important research direction in Geospatial Artificial Intelligence (GeoAI), plays a central role in integrating surveying, mapping, geographic information technologies, and artificial intelligence. It promotes intelligent innovation and enables the deployment of spatial intelligence technologies across diverse real-world application scenarios. In January 2025, a research team from the Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, reviews the history of GeoAI-driven spatiotemporal forecasting, and offers a comprehensive survey of spatial-temporal prediction models including statistical learning, deep learning, and generative large models. This study critically evaluates existing forecasting research and identifies five key challenges in the field. Finally, four future trends and research directions were proposed to advance geospatial intelligent prediction technologies.

A new study has uncovered a novel P-type PPR protein, BoYgl-2, which plays a crucial role in chloroplast RNA editing and chlorophyll biosynthesis in cabbage. 

Research team led by Chuliang Weng introduces D2-GCN, a groundbreaking disentangled graph convolutional network that dynamically adjusts feature channels for enhanced node representation, outperforming traditional methods in node classification tasks.

Research team led by Chuliang Weng introduces D2-GCN, a groundbreaking disentangled graph convolutional network that dynamically adjusts feature channels for enhanced node representation, outperforming traditional methods in node classification tasks.

Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the uterus, leading to severe pain and infertility in affected women. The pathogenesis of endometriosis remains elusive, and effective treatments are limited, highlighting the need for a deeper understanding of its molecular mechanisms. A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic glycolysis in endometriotic cells. This discovery provides novel insights into the disease's pathophysiology and suggests potential therapeutic targets.

Lemons owe their signature tang to citric acid, yet the molecular mechanisms governing its accumulation have long remained a mystery. 

A new study has unveiled the genetic mechanism controlling citric acid content in jujube fruit, identifying a natural mutation in the promoter of the ZjACO3 gene.