Cutting off parasite’s energy supply could help fight malaria
Reports and Proceedings
Updates every hour. Last Updated: 30-Apr-2025 20:08 ET (1-May-2025 00:08 GMT/UTC)
In 2023, malaria caused 597 000 deaths worldwide, according to the World Health Organization, with most occurring in Africa, where the deadliest malaria parasite, Plasmodium falciparum, is most prevalent. Once inside the body of an infected person, the parasite relies on a process called glycolysis—breaking down glucose (a sugar)—to produce energy and stay alive.
A new study at Stellenbosch University (SU) found that blocking the enzymes involved in this process could cut off the parasite’s primary energy source and kill it. Some of these enzymes could also be good targets for new malaria drugs.
A study by Wits University and Harvard confirms that South Africa’s 2013 sodium reduction legislation has successfully lowered blood pressure and improved public health.
Excessive sodium intake increases the risk of cardiovascular disease, which causes 20 million deaths globally each year. South Africa was the first African country to mandate sodium limits in processed foods. Researchers found a 10% drop in sodium intake over seven years, with more people achieving ideal consumption levels. Even small reductions in sodium correlated with lower blood pressure.
The law required sodium cuts in 13 food categories, including bread and processed meats, with reductions of up to 70% by 2016 and further cuts by 2019. Lead researcher Prof. Thomas Gaziano noted that even a slight blood pressure drop could prevent thousands of deaths annually.
Prof. Steve Tollman of Wits Agincourt Unit highlighted that mandatory regulations are more effective than voluntary measures. The study, involving 5,000 adults in rural South Africa, suggests other countries could adopt similar policies to save lives.
Researchers at the University of the Witwatersrand in Johannesburg, South Africa (Wits University) in collaboration with Huzhou University in China have discovered a way to protect quantum information from environmental disruptions, offering hope for more reliable future technologies.
A critically endangered new species of killifish sampled from an ancient forest in Kenya in 2017 and 2018 has been described in the journal Zootaxa. Nothobranchius sylvaticus, from the Latin meaning “pertaining to the forest”, is also the first known endemic killifish to persist in a forest.
A unique analysis of district-level data reveals why inequality is so destructive to the household consumption welfare of people living below the poverty line. During negative economic growth, the welfare of the poor should be the main focus area.
Masimirembwa, a Distinguished Professor at Wits University's Sydney Brenner Institute for Molecular Bioscience (SBIMB), received the award at a ceremony in California, USA, on 7 February.
The PMWC Pioneer Award recognises Masimirembwa’s groundbreaking work in pharmacogenomics, shedding light on how genetic differences influence drug responses across diverse populations.
His contributions have advanced personalised medicine, paving the way for safer, more effective treatments tailored to individual genetic profiles.
Meanwhile, Masimirembwa was named one of the 100 Most Influential Africans by New African Magazine for his foundational work in genomic medicine on the continent.