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Peer-Reviewed Publication
Updates every hour. Last Updated: 22-May-2026 11:16 ET (22-May-2026 15:16 GMT/UTC)
Kyoto, Japan -- Like schools of fish and flocks of birds, our cells too can migrate collectively in coordination with their neighbors. This harmonious movement of cells occurs during embryonic development, wound healing, and cancer metastasis. However, since individual cells can only sense limited local information, how they are able to coordinate as a larger collective has remained poorly understood.
Previous studies have demonstrated that this collective migration involves adhesion between cells and waves of ERK signaling activation, named for the ERK proteins involved, and may also be influenced by ZO-1, a scaffolding protein best known for its role in cell-cell adhesion. Building on this knowledge, a team of researchers at Kyoto University was motivated to uncover the elusive mechanism behind collective cell movement.
Using live-cell imaging of Madin-Darby canine kidney cells -- model mammal cells often used in biomedical studies -- the researchers were able to directly observe the movement of cell collectives. They simultaneously monitored ERK activity using a FRET biosensor and visualized ZO-1 localization using fluorescently tagged ZO-1.
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