In a significant step towards improving targeted cancer therapy, researchers from Japan have developed a novel nanocarrier system that delivers therapeutic antibodies directly to target antigens inside cancer cells. By utilizing a metal-polyphenol network, the system escapes endosomes, enabling intracellular targeting of antibodies, resulting in suppression of tumor growth and enhanced anti-cancer activity, offering a promising tool for targeted cancer therapy.

In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in shaping immune responses within breast cancer microenvironment.

This review focuses on the critical role of amino acid metabolism in breast cancer development and progression. It explains how cancer cells reprogram amino acid usage—especially glutamine, serine, glycine, aspartate, arginine, and tryptophan—to support proliferation, survival, immune evasion, and metastasis. The review emphasizes metabolic heterogeneity among different breast cancer subtypes and explores therapeutic strategies targeting these pathways.