Gender matters in the brain/bone axis. APOE4, the Alzheimer’s risk gene, silently undermines bone quality in women
Peer-Reviewed Publication
In honor of Alzheimer's Awareness Month, we’re exploring the science and stories surrounding Alzheimer’s disease.
Updates every hour. Last Updated: 13-Apr-2026 23:15 ET (14-Apr-2026 03:15 GMT/UTC)
Scientists at the Buck Institute for Research on Aging, along with collaborators at UC San Francisco, have discovered that APOE4, the most common genetic risk factor for Alzheimer’s disease, causes bone quality deficits specifically in female mice, through a mechanism that is invisible to standard imaging and can emerge as early as midlife.
All processes such as wound healing, hair growth, and the replacement of old cells with new ones depend on cell division. During this process, chromosomes inside the cell must be evenly divided between two daughter cells. Even slight errors can lead to cellular abnormalities.
A research team at POSTECH (Pohang University of Science and Technology) has recently uncovered new clues suggesting that a protein called tau plays an important role in this highly regulated process. The findings were published in the international journal Nature Communications.
A team led by HHMI Janelia Research Campus Group Leader Jiefu Li identified proteins that help control how the blood-brain barrier opens and closes, findings that could help researchers design drug delivery strategies for neurological conditions such as Alzheimer’s disease and Parkinson’s disease that more effectively reach the brain.