New study identifies brain-specific RNA and protein biomarkers in blood, paving way for early and easier diagnosis

A new Keck Medicine of USC study suggests that increasing omega-3 levels via supplements has little effect on brain health despite showing evidence that the nutrients directly reach the brain.

Nearly all Michiganders age 50 and over say it’s very important to keep their brains healthy as they grow older, a new poll finds. But less than half (47%) of middle-aged and older Michiganders know that everyday actions can be very important for reducing their future risk of dementia.

Researchers at Niigata University’s Brain Research Institute have discovered that amyloid precursor protein (APP), long associated with Alzheimer’s disease (AD), plays a previously unknown protective role in clearing nuclear-derived waste material via lysosomal exocytosis. Reduced APP function or familial AD-associated APP mutations impair this clearance, promoting neuroinflammation and cell death. The findings suggest that nuclear damage and intracellular waste clearance failure may contribute to AD pathogenesis.