Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis are marked by the buildup of misfolded proteins that slowly destroy brain cells, yet treatments that address this root cause are still lacking. Interestingly, researchers provide a comprehensive review of the role of heat shock protein 70 (Hsp70) molecular chaperones in several neurodegenerative diseases. Notably, Hsp70 exert neuroprotective effects and mitigate the occurrence of pathological protein aggregates.

Researchers at Wakayama Medical University in Japan have discovered that amyloid-b deposits disrupt the formation of the placenta and may therefore contribute to the development of preeclampsia during pregnancy. These amyloid-b deposits are similar to those characteristically found in the brains of Alzheimer’s disease patients. The findings were published January 20 in the journal Life Science Alliance.

Memantine, a long-approved and cost-effective drug used to treat Alzheimer’s disease, could also benefit patients with sickle cell anemia in the future. Initial clinical data from an international research group led by the University of Zurich (UZH) indicate that the active ingredient is well tolerated, reduces symptoms and improves quality of life in people suffering from this genetic disease.