A team of international researchers has published a comprehensive review in Advanced Science detailing how combining protein three-dimensional spatial structures with artificial intelligence is reshaping the way scientists predict and design drug combinations. By integrating high-resolution protein modeling with advanced AI algorithms, the approach offers unprecedented accuracy in identifying synergistic and antagonistic effects, paving the way for safer and more effective treatments for cancer, infectious diseases, and metabolic disorders.

How do you teach architecture that truly matters? By empowering students to design real projects, for real communities.

From Connecticut to Florida, to the Midwest and beyond, students and faculty at the Yale School of Architecture are building community-first solutions with lasting impact — expanding housing access, advancing sustainability, and rethinking how we shape the built environment.

Innovation That Matters: Episode 2 shows how hands-on learning at Yale is driving real-world change. 

Fighting off pathogens is a tour de force that must happen with speed and precision. A team of researchers at CeMM and MedUni Vienna led by Christoph Bock and Matthias Farlik has investigated how macrophages—immune cells that are the body’s first responders—master this challenge. Their study, published in Cell Systems (DOI: 10.1016/j.cels.2025.101346), offers a time-resolved analysis of the molecular processes that unfold when these cells encounter various pathogens. They developed a new method that combines gene editing and machine learning, which identified key regulators of macrophage immune responses.

The Center for Interactive Media has established five goals and will also address the growing gap in Georgia’s digital economy by integrating human-centered, user-experience research, ethical artificial intelligence (AI) design, and immersive media development into a unified research and development pipeline. Plans for the center include building a physical space with a virtual and augmented reality room, a game studio, motion capture and sound room, and a focus room for user experience. In addition, the CIM will establish a presence in the metaverse, a virtual reality environment.

The accurate estimation of bearing stratum depth, the subsurface soil or rock layer depth that can support a foundation, is key to preventing soil-related disasters in earthquake-prone areas and ensuring a building’s structural safety. However, traditional methods to assess this depth involve high costs, time, and labor. Now, researchers from Japan have demonstrated improved depth prediction accuracy by employing machine learning algorithms, making it both cost-effective and a generalizable alternative to traditional field surveys.

Newly developed DNA nanostructures can form flexible, fluid, and stimuli-responsive condensates without relying on chemical cross-linking, report researchers from Institute of Science Tokyo and Chuo University. Owing to a rigid tetrahedral motif that binds the linkers in a specific direction, the resulting string-like structures form condensates with exceptional fluidity and stability. These findings pave the way for adaptive soft materials with potential applications in drug delivery, artificial organelles, and bioengineering platforms.