JMC Publication: Insilico’s Chemistry42 empowered efficient discovery of potent, oral CBLB inhibitor for immuno-oncology
Peer-Reviewed Publication
This month, we’re focusing on artificial intelligence (AI), a topic that continues to capture attention everywhere. Here, you’ll find the latest research news, insights, and discoveries shaping how AI is being developed and used across the world.
Updates every hour. Last Updated: 13-Dec-2025 11:11 ET (13-Dec-2025 16:11 GMT/UTC)
Targeting Casitas B-lineage lymphoma-b (CBLB), Insilico Medicine announced the nomination of ISM3830, its 23rd AI-empowered preclinical candidate (PCC) since 2021, in late November 2025, which demonstrated low toxicity risks, favorable ADME/PK profiles, as well as induction of long-term tumor immunity, cracking the bottleneck in metabolism and absorption of previously reported CBLB inhibitors.
Shortly beforehand, the discovery process and evaluation of CBLB inhibitors with a different scaffold were published in the Journal of Medicinal Chemistry. The paper highlights Compound 10, a potent, orally available lead compound with novel scaffold promising druggability, providing an AI-driven optimization roadmap for CBLB inhibition strategies.
Dementia, including Alzheimer’s (AD) and frontotemporal dementia (FTD), often causes overlapping symptoms, making diagnosis challenging. Traditional imaging is costly and slow, while EEG offers a cheaper, portable option—but interpreting signals has been difficult. FAU researchers have developed a deep learning model that analyzes EEG brain activity to accurately detect both type and severity of dementia. This AI-driven approach identifies key brainwave patterns, enabling faster, noninvasive, and precise monitoring of disease progression, transforming dementia diagnosis and care.
A new study shows that merely imagining a positive encounter with someone can make you like them better by engaging brain regions involved with learning and preference. The findings could have implications for psychotherapy, sports performance and more.
When you’re swaying in a beachside hammock on a lazy summer day, take a moment to thank the Indigenous cultures that invented it.
Native to South America and the Caribbean, hammocks were traditionally woven by women, who were frequently fiber-workers in Indigenous cultures, said Binghamton University Associate Professor of English John Kuhn, who recently co-authored an article on the topic.
“The oldest preserved specimen is 4,000 years old, but they may actually be much older,” said Kuhn, who also directs the Institute for Advanced Studies in the Humanities at Binghamton. “We just don’t know; textiles don’t preserve well in the tropics.”
Co-authored by Marcy Norton at the University of Pennsylvania, “Towards a history of the hammock: An Indigenous technology in the Atlantic world” recently appeared in postmedieval: a journal of medieval cultural studies.
Portable, versatile and easy to clean, hammocks are a comfortable way to sleep in a hot climate. They also protect the user from insects, especially when compared to the ground-based bedding common to European colonizers.
“Colonists basically adopt them right from the jump,” Kuhn said. “They learn to use them because the hammock was a major component in hospitality rituals that are being extended to them by Indigenous groups who are seeking alliance and friendship.”
The technology proved useful for military expeditions in the Americas and was adopted by figures such as English explorer Sir Walter Raleigh. As colonial settlements began to develop, their use was adopted by a wider population, from elites to slaves.
Hammocks are also connected to Indigenous culture with deep webs of meaning. In addition to sleep, the bed-slings were used as private spaces to chat, manufacture objects or play music. In short, they were a way to define an individual’s personal space in an otherwise communal culture.
“We know from one Kalinago-French dictionary compiled in the early colonial period that the word for hammock was linguistically linked to the word for placenta,” Kuhn said. “It’s kind of poetic: You’re in one kind of container and then, because hammocks are given to babies right away, you move to another one after you’re born.”
Not only did individuals enter the world in a hammock, they left it in one, too; hammocks were also used as burial shrouds. They even played a role in religious life, as a vessel for healing rituals and trance states in which shamans would commune with spirits.
The spread of hammock use among colonizers belies the common belief that European technology was far superior to that of Indigenous people. It’s far from the only example of cultural borrowing; take chocolate and tobacco, which originated as stimulants developed by Indigenous cultures.
Kuhn is currently working on a book about another Indigenous technology: birchbark canoes, which North American colonists immediately adopted for their own use.
“Sometimes people have this idea that Indigenous cultures were just destroyed, and they aren’t necessarily seen as huge technological contributors to the Atlantic world that emerges out of colonization,” Kuhn said. “The next time you see a hammock, just take a minute to marvel at the ingenuity of the cultures that it sprang from!”
About Binghamton University
Binghamton University, State University of New York, is the #1 public university in New York and a top-100 institution nationally. Founded in 1946, Binghamton combines a liberal arts foundation with professional and graduate programs, offering more than 130 academic undergraduate majors, minors, certificates, concentrations, emphases, tracks and specializations, plus more than 90 master's, 40 doctoral and 50 graduate certificate programs. The University is home to nearly 18,000 students and more than 150,000 alumni worldwide. Binghamton's commitment to academic excellence, innovative research, and student success has earned it recognition as a Public Ivy and one of the best values in American higher education.
Researchers from Wroclaw Medical University investigated why some transplanted kidneys deteriorate despite treatment, focusing on a type of rejection called microvascular inflammation (MVI). This form of injury, now highlighted in the updated Banff 2022 Classification, is difficult to detect without biopsy and is often not accompanied by classic markers such as anti-HLA antibodies. To address this diagnostic gap, the team examined the role of non-HLA antibodies, particularly those targeting the angiotensin II type 1 receptor (AT1R).
In a study of 167 transplant recipients, MVI was significantly more common in patients with elevated AT1R antibody levels. Using advanced analytical methods, including artificial intelligence, the researchers identified that only high AT1R titers (>12 U/ml) meaningfully increased the risk of MVI. This suggests that non-HLA antibodies may contribute to graft injury in cases where traditional tests remain negative.
The findings open a path toward developing a more comprehensive, minimally invasive immunological profile to support early diagnosis of rejection. According to the authors, AI-assisted tools may become an essential part of transplant medicine, helping clinicians detect risk sooner and prolong the lifespan of transplanted kidneys.