A team led by Professor Jianping Jia from Xuanwu Hospital of Capital Medical University published significant findings in the Chinese Medical Journal. They developed a novel blood test using ultrasonic protein misfolding cyclic amplification technology. By detecting plasma amyloid beta aggregation seeding activity, this method accurately diagnoses Alzheimer’s disease and mild cognitive impairment. Achieving over 90 percent diagnostic accuracy, it provides an important minimally invasive tool for early and differential diagnosis of the disease.

Many diseases, including Alzheimer's, ALS and type 2 diabetes, are driven by proteins that misfold and clump together. A new review highlights growing evidence that the greatest harm may come from small protein clumps known as oligomers, which appear early in the disease process, long before larger deposits become visible.