Zhaoqi Yan, PhD, a scientist at Gladstone Institutes, has been named a 2025 Warren Alpert Distinguished Scholar. His innovative research on blood proteins that leak into the brain could eventually lead to new therapies for a wide range of neurological conditions, including Alzheimer’s disease.

Over 6 million Americans are impacted by Alzheimer’s disease, and researchers from Vanderbilt University Medical Center and the University of Pittsburgh  are discovering how lifestyle habits can impact the likelihood of developing the disease. According to a new research study published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, researchers found that increased sedentary behavior, time spent sitting or lying down, in aging adults was associated with worse cognition and brain shrinkage in areas related to risk for developing Alzheimer’s disease.

Mitochondrial DNA (mtDNA) editing has emerged as a revolutionary approach in the fight against neurodegenerative diseases (NDDs). As these diseases continue to impose a significant global health burden, the innovative use of mitochondrial gene editing offers a promising avenue to address their underlying causes. The dysfunction of mitochondria, triggered by mutations in mtDNA, is now recognized as a pivotal factor contributing to the development of several debilitating conditions, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and Amyotrophic Lateral Sclerosis (ALS).

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