Scientists from the University of Oslo (UiO), Akershus University Hospital (Ahus), and international partners have released a new expert opinion in Nature Aging. The article brings together more than 25 researchers from around the world, including clinicians and internationally recognised leaders in the biology of ageing and metabolism, particularly in the study of nicotinamide adenine dinucleotide (NAD⁺). Their collective perspective underscores the global effort to understand how this tiny molecule, NAD⁺, could be key to healthier ageing and protection against diseases such as Alzheimer’s and Parkinson’s.

Researchers at the Indiana University School of Medicine, Eskenazi Health, Regenstrief Institute and other partners have demonstrated the feasibility of conducting dementia prevention trials among older adults with limited formal education, a group at heightened risk for Alzheimer’s disease and related dementias.

The MINDSpeed trial, a randomized study, tested whether a diet rich in polyphenols, which are plant-based compounds found in foods like nuts and berries, and online speed-of-processing cognitive training could improve cognition in older adults with 12 or fewer years of education.