15-Dec-2025
Day & night: Cancer disrupts the brain’s natural rhythm
Cold Spring Harbor LaboratoryPeer-Reviewed Publication
"It's been known for decades that cancer can flatten healthy day-night stress hormone rhythms,” says CSHL’s Jeremy Borniger. “What causes that?” In mice, Borniger’s lab found that breast cancer disrupts the brain-body feedback loop that regulates these rhythms. Stimulating key neurons in the hypothalamus at certain times restored healthy function, pushing anti-cancer immune cells into tumors and shrinking them significantly.
- Journal
- Neuron
- Funder
- NIH/National Institutes of Health, NIH/National Cancer Institute, American Association for Cancer Research, U.S. Department of Defense, NIH/National Institute on Aging, Brain and Behavior Research Foundation, Howard Hughes Medical Institute, Rita Allen Foundation, McKnight Foundation, Simons Foundation, Esther A. and Joseph Klingenstein Fund