In situ generation of NKG2D CAR T/NK cells via a tumor-targeted lipoplex for enhancing cancer immunotherapy
Peer-Reviewed Publication
This month, we're turning our attention to Breast Cancer Awareness Month, a time dedicated to increasing awareness, supporting early detection, and highlighting the ongoing research shaping the future of breast cancer treatment and prevention.
Updates every hour. Last Updated: 19-Oct-2026 21:16 ET (20-Oct-2026 01:16 GMT/UTC)
A research team from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, has developed a hypoxia-responsive, tumor-penetrating lipoplex that can generate NKG2D CAR-T and NK cells directly within solid tumors. This dual-controlled strategy enables local CAR generation in triple-negative breast cancer via targeting GRM4 and utilizing a hypoxia-inducible promoter, significantly enhancing antitumor immunity while minimizing off-target expression and inflammatory side effects. This study offers a promising precision strategy to engineer CARs in solid tumors with enhanced safety.
A deeper understanding of mitochondrial function could create new opportunities for treating triple-negative breast cancer (TNBC), one of the most aggressive and difficult-to-treat forms of breast cancer. The complex relationship between mitochondrial dynamics, energy metabolism and cancer-cell survival is revealing potential targets that could support more personalized treatment strategies.