About The Study: In this cohort study, most participants with pathogenic variants (PVs) in breast cancer genes would not have been recommended for high-risk screening based on their clinical or clinical plus polygenic risk. PV testing therefore may identify different subsets of high-risk women than clinical risk factors and polygenic risk scores. These findings highlight the importance of population-based PV testing in risk-based screening. 

Obesity may change how early-stage breast cancer becomes invasive, according to a study by University of Oklahoma researchers published in The American Journal of Pathology.

OSUCCC – James researchers will present new findings at the 2026 American Society of Clinical Oncology (ASCO) annual meeting, including a program that helps patients get donated oral drugs faster, new insights into colon and breast cancer, and ongoing accessibility gaps across communities in clinical trials.

Immunotherapies such as so-called checkpoint inhibitors activate the body’s own immune system to fight cancer cells and have revolutionised the treatment of many types of tumour. In breast cancer, however, these therapies are often only of limited effectiveness. An international research team led by the Medical University of Vienna has now identified a previously underestimated mechanism by which breast tumours evade the immune system. The findings, currently published in the journal Nature Communications, also provide a new starting point for improving the effectiveness of immunotherapies in breast cancer.