EurekAlert! In the Spotlight - Breast Cancer Awareness

This month, we're turning our attention to Breast Cancer Awareness Month, a time dedicated to increasing awareness, supporting early detection, and highlighting the ongoing research shaping the future of breast cancer treatment and prevention.

Circular RNA-encoded protein SCAP-129aa drives platinum resistance in triple-negative breast cancer, new study from Sun Yat-Sen University finds

Science China Press
Peer-Reviewed Publication

A team from Sun Yat-sen University Sun Yat-sen Memorial Hospital has identified a novel mechanism underlying platinum resistance in triple-negative breast cancer (TNBC): the circular RNA circSCAP encodes a 129-amino-acid protein (SCAP-129aa) that activates the PI3K/AKT pathway by stabilizing PIK3R2. Silencing circSCAP or combining platinum therapy with the PIK3R2 inhibitor significantly improved treatment efficacy in preclinical models, highlighting circSCAP and SCAP-129aa as potential biomarkers and therapeutic targets.

Journal: Science China Life Sciences

15-Sep-2025

Microarray analysis of differential expression of long non-coding RNAs in peripheral blood mononuclear cells in luminal a breast cancer

Xia & He Publishing Inc.
Peer-Reviewed Publication

In the post-genomic era, long non-coding RNAs (lncRNAs) have emerged as critical regulators in various cancers and hold potential as minimally invasive diagnostic biomarkers. This study aimed to perform microarray analysis of the peripheral blood mononuclear cell (PBMC) transcriptome to evaluate differential lncRNA expression in women with luminal A breast cancer.

Journal: Gene Expression

14-Sep-2025

Both weights and HIIT offer health benefits for cancer survivors

Edith Cowan University
Peer-Reviewed Publication

Research from Edith Cowan University (ECU) has revealed that both resistance training and high intensity interval training (HIIT) produced sufficient levels of myokines to help in the fight against cancer.

Journal: Medicine & Science in Sports & Exercise

12-Sep-2025

Developmental biologist Maria Jasin wins the 2025 Pearl Meister Greengard Prize

Rockefeller University
Grant and Award Announcement

Jasin's fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations. She will be presented with the award on September 16.

9-Sep-2025

Study of breast cell changes in motherhood provides clues to breastfeeding difficulties

University of Cambridge
Peer-Reviewed Publication

A University of Cambridge study of adult mammary gland development has revealed new genes involved in breastfeeding, and provided insights into how genetic changes may be associated with breastfeeding disorders and postpartum breast cancers.

Journal: Nucleic Acids Research
Funder: Medical Research Council

8-Sep-2025

How does chemotherapy disrupt circadian rhythms?

Society for Neuroscience
Peer-Reviewed Publication

Using female mice, researchers find that a frequently used breast cancer treatment impairs molecular and behavioral measures of the primary biological clock found in the brain.

Journal: eNeuro
Funder: NIH/National Cancer Institute

5-Sep-2025

MD Anderson research highlights for September 5, 2025

University of Texas M. D. Anderson Cancer Center
Peer-Reviewed Publication

Clinical trials show promising results in treating pancreatic and colorectal cancers

New treatment strategies improve outcomes for patients with kidney and testicular cancers

Novel research techniques enable advances in gene-drug interactions, breast cancer progression, and identifying pre-cancerous lesions

Biomarkers help predict risk for oral cancer metastasis

Welcome to In the Spotlight, where each month we shine a light on something exciting, timely, or simply fascinating from the world of science.

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