In APL Bioengineering, researchers design and test a hand-held device to differentiate tumors from healthy tissue using the tissues’ mechanical properties. The probe is based on optical elastography, which combines imaging with mechanical measurements like elasticity. When compressed, tumors and healthy tissue exhibit different mechanical properties, and this can be measured by the probe. Since the probe also provides a visual of the tissue, users have another data point to differentiate the two tissue types.

Low doses of the investigational medicinal product endoxifen reduce breast density to the same extent as the standard treatment tamoxifen, but without causing such troublesome side effects. This is shown by a new study from Karolinska Institutet published in the Journal of the National Cancer Institute. The results may have implications for future preventive treatment of breast cancer.

Breast cancer remains a leading cause of malignancy-related mortality among women globally, with triple-negative breast cancer (TNBC) posing a significant clinical challenge due to its aggressive nature and early metastatic potential. Previous studies have implicated obesity in driving tumor progression, often associating it with diminished therapeutic responses and poor survival outcomes.

A peptide that successfully targeted and killed metastatic cancer cells in mice may open the door to developing more efficient ways to detect and treat metastatic breast cancer in humans, UTHealth Houston researchers have discovered.