From metabolism to immunity: a hidden switch in breast cancer uncovered
Peer-Reviewed Publication
This month, we're turning our attention to Breast Cancer Awareness Month, a time dedicated to increasing awareness, supporting early detection, and highlighting the ongoing research shaping the future of breast cancer treatment and prevention.
Updates every hour. Last Updated: 16-Dec-2025 21:11 ET (17-Dec-2025 02:11 GMT/UTC)
In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in shaping immune responses within breast cancer microenvironment.
Recent research highlights the transformative impact of precision medicine on breast cancer management. By tailoring treatments to the unique genetic and molecular profiles of individual tumors, precision medicine has significantly improved outcomes for patients across all major breast cancer subtypes. Key innovations, including advanced diagnostics, targeted therapies, and immunotherapy, are reshaping the landscape of breast cancer care.
This review focuses on the critical role of amino acid metabolism in breast cancer development and progression. It explains how cancer cells reprogram amino acid usage—especially glutamine, serine, glycine, aspartate, arginine, and tryptophan—to support proliferation, survival, immune evasion, and metastasis. The review emphasizes metabolic heterogeneity among different breast cancer subtypes and explores therapeutic strategies targeting these pathways.