In this study, the researchers found that the excess number of breast cancer cases detected in the randomised trials closely matched what would be expected in a Danish screening population, where overdiagnosis is estimated to be below 5%.

Highlights

• Integrin alpha 3 (ITGA3) protein expression was detected in approximately 85% of breast cancer specimens by immunohistochemistry.

• ITGA3 expression was significantly higher in human epidermal growth factor receptor 2 (HER2)-positive and hormone receptor(HR)-positive/HER2-negative breast cancer than in triple-negative breast cancer (TNBC).

• High ITGA3 protein expression was associated with shorter 5-year recurrence-free survival.

• ITGA3 alterations in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort were associated with worse relapse-free and overall survival.

• Integrin α3β1 represents a potential prognostic biomarker and therapeutic target warranting prospective validation.

An artificial intelligence model that analyzes women’s past and recent annual 3D mammograms is more effective at predicting five-year risk of developing breast cancer than a tool that uses only the most recent, single 3D mammogram, as well as an AI model that analyzes 2D mammograms, a new study shows.