A new cardiac magnetic resonance imaging-based measurement may improve how physicians assess a common heart valve condition, according to a study led by Weill Cornell Medicine and NewYork-Presbyterian investigators. The findings support the broader use and further study of the new metric known as effective right ventricular ejection fraction (eRVEF).

Since their discovery in the 1950s, metallocenes — chemical compounds where a metal atom sits ‘sandwiched’ between two carbon rings — have been at the heart of organometallic chemistry research, finding applications in catalysis, materials design, energy, sensing, drug delivery and more. Yet knowledge of their formation has been limited, due to the transient nature of their unstable intermediates.

Published in the Journal of the American Chemical Society (JACS), researchers from the Okinawa Institute of Science and Technology (OIST) have reported the first full structural characterization of a doubly ring-slipped reaction intermediate in the formation of a metallocene. With its unusual structure, the characterization provides new evidence of how metallocenes may form, break and react, presenting design opportunities for stimuli-responsive, metallocene-based materials for a wide variety of potential applications.