Leprosy in the Americas predates European contact, new study finds
Peer-Reviewed Publication
In honor of Indigenous Peoples' Day, we’re exploring how Indigenous communities contribute to science, conservation, health research, and much more.
Updates every hour. Last Updated: 7-Sep-2025 21:11 ET (8-Sep-2025 01:11 GMT/UTC)
Leprosy has been present in the Americas for more than 1,000 years, long before the arrival of European settlers, according to a groundbreaking new international study co-led by scientists at Colorado State University and the Institut Pasteur in France, in collaboration with Indigenous communities and more than 40 scientists from institutions across the Americas and Europe. The study reframes the history of leprosy in the Americas and has implications for better understanding how infectious diseases spread, persist and evolve in human and animal populations over time.
The magnitude and complexity of road traffic injuries for Aboriginal and Torres Strait Islander people is compounded by a problematic compensation system with structural barriers and systemic inequities according to new research by Flinders University.
Macrophotography and bee hotels introduced Dr Kit Prendergast to the world of native bees. Inspired, she began her PhD on protecting native bee biodiversity in urbanised habitats, and investigating the role of the introduced European honey bee on indigenous bee biodiversity and pollination networks. Since completing her PhD, she has worked in diverse roles as an ecological consultant, working to conduct native bee research for not-for-profits, environmental consultancies, Landcare groups, and local and state government, as well as with research institutions. She was awarded a Federal Government Grant to lead a project using bee hotels to help with the recovery of native cavity-nesting bees after the 2019/2020 bushfires. She is also a prolific science communicator, and has won a number of awards for her articles and scientific outreach.
Prendergast is the corresponding author of a new article in Frontiers in Bee Science which explores the impact that invasive honey bees have on native Australian cavity-nesting bees, and has kindly taken the time to share some thoughts about her career and research as part of the Frontier Scientists series.
A new study combining Indigenous knowledge systems with Western genomics has uncovered how megafauna – namely ancient horses – were impacted during a period of substantial habitat change. During the late Pleistocene, the study reports, horses repeatedly migrated between North America and Eurasia, but after the Last Glacial Maximum, warming caused a land bridge to be submerged, severing this connection, and ultimately contributing to horses’ decline in North America. The findings could inform modern conservation approaches. Large animals, or megafauna, play critical roles in maintaining ecological balance. Their decline can lead to far-reaching disruptions for both natural and human communities. These risks are particularly pronounced in the rapidly warming Arctic. Indigenous scientific systems have long documented how shifts in climate reshape habitats. Complementing this, the fossil record offers a deep-time perspective on how local megafauna responded to past periods of rapid environmental change. Pleistocene-age horses in Beringia – a once-continuous landmass connecting Asia to North America – are a good model of megafauna so impacted. Still, despite dramatic environmental shifts during the Late Pleistocene, the effects on Beringian horse populations and their legacy remain poorly understood.
To trace how horses responded to environmental shifts over the past 50,000 years, Yvette Running Horse Collin and colleagues merged geochemical and genetic analyses of ancient Beringian horse fossils with Indigenous scientific protocols. Running Horse Collins et al. generated genomes from 67 ancient horse fossils found across Beringia, Siberia, and continental North America and analyzed them alongside data from all known horse lineages. They integrated their genomic data with radiocarbon dates and stable isotope measurements from fossil horse collagen. The findings reveal repeated trans-Beringian horse migrations between 50,000 and 13,000 years ago, with genetic exchanges occurring in both directions – from North America to Eurasia and vice versa. Some horse lineages in Eurasia, including fossils from northeastern Siberia and even as far west as Iberia, show traces of North American ancestry, supporting widespread dispersals. According to the authors, this complex genetic legacy mirrors the interconnectivity emphasized in Indigenous knowledge systems, which view life forms as deeply relational, not isolated. Moreover, the study also suggests that habitat changes due to warming and deglaciation at the Pleistocene-Holocene transition – particularly the shift from dry grasslands to wet, boggy tundra – limited horse mobility and food access, contributing to population decline in North America. In contrast, generalist herbivores such as moose and elk flourished.
These patterns underscore a broader ecological principle found in Indigenous science, particularly the Lakota concept of mitakuye oyasin, which emphasizes that a species’ survival depends not only on geography, but also its relationship with other life forms within a shared, interdependent habitat. Changes to this relational habitat can serve as the driving force for movement or migration.
For reporters interested in further insights into how this work was done, author Ludovic Orlando said, “Establishing collaborations with Indigenous scientists grounded in mutual respect and equal partnership is essential for the future of all scientific disciplines. Indigenous communities have cultivated deep and invaluable knowledge systems over countless generations. However, the structure of project-based science – often driven by tight funding cycles and publication deadlines – can pose challenges to meaningful cross-cultural dialogue and may not always align with Indigenous protocols for sharing traditional knowledge. The co-authors of this study have worked under the guidance of an Indigenous Review Board to ensure that every stage of the research – from study design to publication – respects and adheres to Indigenous protocols. We hope our approach can serve as a valuable model for other researchers and help foster broader adoption of ethically grounded, collaborative scientific practices.”
A new study combining Indigenous knowledge systems with Western genomics has uncovered how megafauna – namely ancient horses – were impacted during a period of substantial habitat change. During the late Pleistocene, the study reports, horses repeatedly migrated between North America and Eurasia, but after the Last Glacial Maximum, warming caused a land bridge to be submerged, severing this connection, and ultimately contributing to horses’ decline in North America. The findings could inform modern conservation approaches. Large animals, or megafauna, play critical roles in maintaining ecological balance. Their decline can lead to far-reaching disruptions for both natural and human communities. These risks are particularly pronounced in the rapidly warming Arctic. Indigenous scientific systems have long documented how shifts in climate reshape habitats. Complementing this, the fossil record offers a deep-time perspective on how local megafauna responded to past periods of rapid environmental change. Pleistocene-age horses in Beringia – a once-continuous landmass connecting Asia to North America – are a good model of megafauna so impacted. Still, despite dramatic environmental shifts during the Late Pleistocene, the effects on Beringian horse populations and their legacy remain poorly understood.
To trace how horses responded to environmental shifts over the past 50,000 years, Yvette Running Horse Collin and colleagues merged geochemical and genetic analyses of ancient Beringian horse fossils with Indigenous scientific protocols. Running Horse Collins et al. generated genomes from 67 ancient horse fossils found across Beringia, Siberia, and continental North America and analyzed them alongside data from all known horse lineages. They integrated their genomic data with radiocarbon dates and stable isotope measurements from fossil horse collagen. The findings reveal repeated trans-Beringian horse migrations between 50,000 and 13,000 years ago, with genetic exchanges occurring in both directions – from North America to Eurasia and vice versa. Some horse lineages in Eurasia, including fossils from northeastern Siberia and even as far west as Iberia, show traces of North American ancestry, supporting widespread dispersals. According to the authors, this complex genetic legacy mirrors the interconnectivity emphasized in Indigenous knowledge systems, which view life forms as deeply relational, not isolated. Moreover, the study also suggests that habitat changes due to warming and deglaciation at the Pleistocene-Holocene transition – particularly the shift from dry grasslands to wet, boggy tundra – limited horse mobility and food access, contributing to population decline in North America. In contrast, generalist herbivores such as moose and elk flourished.
These patterns underscore a broader ecological principle found in Indigenous science, particularly the Lakota concept of mitakuye oyasin, which emphasizes that a species’ survival depends not only on geography, but also its relationship with other life forms within a shared, interdependent habitat. Changes to this relational habitat can serve as the driving force for movement or migration.
For reporters interested in further insights into how this work was done, author Ludovic Orlando said, “Establishing collaborations with Indigenous scientists grounded in mutual respect and equal partnership is essential for the future of all scientific disciplines. Indigenous communities have cultivated deep and invaluable knowledge systems over countless generations. However, the structure of project-based science – often driven by tight funding cycles and publication deadlines – can pose challenges to meaningful cross-cultural dialogue and may not always align with Indigenous protocols for sharing traditional knowledge. The co-authors of this study have worked under the guidance of an Indigenous Review Board to ensure that every stage of the research – from study design to publication – respects and adheres to Indigenous protocols. We hope our approach can serve as a valuable model for other researchers and help foster broader adoption of ethically grounded, collaborative scientific practices.”