Daily sedentary behavior and physical activity are associated with exercise capacity in adult patients with congenital heart disease
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Updates every hour. Last Updated: 4-May-2025 21:09 ET (5-May-2025 01:09 GMT/UTC)
AIMR researchers used micro-focused ARPES to identify domain-specific surface states in antiferromagnetic NdSb that disappear above 16 K. This suggests bulk spin order induces these states through symmetry-breaking, potentially enabling control of surface electrons for applications in spintronics and quantum technologies.
While small-scale open-sourcing efforts had been attempted in the past, this project has realized one of the largest-scale open-sourcing initiatives globally. This software can customize set-up through operation to meet users’ needs. This is expected to pave the way for practical quantum computers in the future and contribute to solving social issues through their application.
An Osaka Metropolitan University-led study examines the relationship between the insulin-like peptide 3 (INSL3) receptor (RXFP2) expression levels on spermatozoa and INSL3 concentrations in the seminal plasma of fresh semen from beef bulls with different levels of sperm morphological normality.
A research group led by Associate Professor Takashi Kikuchi and Professor Wei Li from the Department of Pharmacognosy at the Faculty of Pharmaceutical Sciences, Toho University, along with Professor Atsushi Sugiyama from the Department of Pharmacology at the Faculty of Medicine and Industry-Academia Collaboration Advisor Katsuhiko Ito, has analyzed the chemical compounds of the roots of Codonopsis lanceolata (commonly known as “Tsuruninjin”) grown in Nagano Prefecture. Their findings have revealed the compounds of the plant and, in particular, demonstrated that its major compound, lancemaside A, exhibits vasodilatory effects, suggesting that Codonopsis lanceolata could be effectively utilized as a health-promoting material in the future.
This research was published in the academic journal Chemistry on January 6, 2025.
An international collaborative research group led by Prof. Masatoshi Kudo, MD (Chair, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine) conducted a multicenter, randomized, double-blind, phase 3 study and demonstrated that the combination of the molecular targeted agent lenvatinib and the immune checkpoint inhibitor pembrolizumab in addition to the conventional treatment of transarterial chemoembolization (TACE) in patients with unresectable non-metastatic hepatocellular carcinoma (HCC) significantly extended progression-free survival and showed a trend toward extending overall survival compared to TACE alone. Based on the results of this study, it is anticipated that lenvatinib plus pembrolizumab, in combination with TACE, will become the standard of care for patients with unresectable non-metastatic HCC and may lead to a complete cure.