Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, researchers have discovered that lysosomal lipid peroxidation plays a critical role in the execution of ferroptosis. They also showed that this leads to iron leakage from the lysosome, further promoting ferroptosis. Additionally, administration of chloroquine—a drug that promotes lysosomal membrane damage—facilitates ferroptosis in cancer cells that are less sensitive to the process.

Estimating the pose of hand-held objects is a critical and challenging problem in robotics and computer vision. While leveraging multi-modal RGB and depth data is a promising solution, existing approaches still face challenges due to hand-induced occlusions and multimodal data fusion. In a new study, researchers developed a novel deep learning framework that addresses these issues by introducing a novel vote-based fusion module and a hand-aware pose estimation module.

Estrogens are known for their role in reproduction, but a new study from Fujita Health University, Japan, reveals that neuroestrogens—estrogens produced in the brain—play a key role in appetite regulation. These brain-made hormones enhance the expression of a hunger-suppressing receptor in the hypothalamus and improve leptin sensitivity. The findings highlight a new biological pathway that could lead to innovative strategies for managing obesity and eating disorders.