MULTI-evolve: Rapid evolution of complex multi-mutant proteins
Peer-Reviewed Publication
This month, we’re focusing on artificial intelligence (AI), a topic that continues to capture attention everywhere. Here, you’ll find the latest research news, insights, and discoveries shaping how AI is being developed and used across the world.
Updates every hour. Last Updated: 15-May-2026 10:16 ET (15-May-2026 14:16 GMT/UTC)
Researchers at Arc Institute developed MULTI-evolve, an AI-guided framework that compresses protein engineering from months of iterative experimentation into weeks using as few as 200 strategic lab measurements. By training neural networks on pairwise combinations of beneficial mutations, the approach learns the rules of how mutations interact and accurately predicts complex multi-mutant proteins, achieving up to 256-fold activity improvements in a single experimental round. Published in Science, the framework and open-source tools are applicable to enzymes, genome editors, and therapeutic proteins.
A team of researchers has found a way to steer the output of large language models by manipulating specific concepts inside these models. The new method could lead to more reliable, more efficient, and less computationally expensive training of LLMs. But it also exposes potential vulnerabilities. The researchers present their findings in the Feb. 19, 2026, issue of the journal Science.
Harvard researchers have developed OpenMetabolics, an open-source, smartphone-based activity monitor that uses machine learning and leg motion to estimate calories burned.
Researchers from the Department of Computer Science at Bar-Ilan University and from NVIDIA’s AI research center in Israel have developed a new method that significantly improves how artificial intelligence models understand spatial instructions when generating images – without retraining or modifying the models themselves.
Pygmy sperm whales are elusive deep divers rarely seen alive. Scientists rely on stranded individuals, especially along the southeastern U.S., to study them. Researchers analyzed more than 20 years of stranding data and identified three previously unknown Helicobacter genotypes in whale stomach tissue. Detected through histopathology, molecular diagnostics and DNA sequencing, the bacteria were linked to ulcers and inflammation, expanding knowledge of this little-known species and ocean microbes.