New study links longer reproductive years to healthier brain aging in women
Peer-Reviewed Publication
In honor of Alzheimer's Awareness Month, we’re exploring the science and stories surrounding Alzheimer’s disease.
Updates every hour. Last Updated: 26-Jul-2025 19:10 ET (26-Jul-2025 23:10 GMT/UTC)
Scientists at Sanford Burnham Prebys and elsewhere have recently reported real-world links in medical records associating common HIV drugs with a reduced incidence of Alzheimer’s disease. The studies showed patients were at less risk of developing Alzheimer’s disease if they were taking drugs to block a famous enzyme called reverse transcriptase, which copies RNA into DNA.
Jerold Chun, MD, PhD, and colleagues at Sanford Burnham Prebys looked for evidence of actual reverse transcriptase activity in the aging human brain and in brains affected by Alzheimer’s disease, identifying reverse transcriptase enzymatic activity, and novel RNAs that encode brain reverse transcriptases especially in neurons of the aging human brain.