A web tool designed to spark reminiscence could help people with dementia and their caregivers feel more connected to each other and less impacted by feelings of pre-death grief, according to a clinical trial co-led by USC and Weill Cornell Medicine published in JAMA Network Open.

With features such as photo albums, autobiographical questions, and journaling prompts, the Living Memory Home for Dementia Care Pairs (LMH-4-DCP) website is a customizable virtual space that facilitates collaborative and interactive reminiscence therapy for both dementia patients and caregivers, said lead author Francesca Falzarano, assistant professor at the USC Leonard Davis School of Gerontology.

New research from Boston Children’s Hospital, published in Cell, finds that the brain’s resident immune cells, microglia, amass mutations in specific cancer-driving genes yet they don’t manifest as cancer. Instead, these mutations may help drive Alzheimer’s disease. These findings may provide insights into new Alzheimer’s disease diagnostics and treatments.

Researchers have found evidence that a therapeutic strategy which makes the brain work more efficiently to learn and recall memories may in fact help to target compromised brain activity in Alzheimer’s disease.

The study led by University of Galway focused on nerve cells which routinely limit or restrict activity and messages being sent by the brain, rather than the more conventional approach of therapy for nerve cells which stimulate activity.

Alzheimer’s disease is a chronic progressive neurodegenerative disorder with clinical symptoms including diminished memory and cognitive function. It is the most prevalent cause of dementia, accounting for 60-80% of dementia cases. Alzheimer’s disease and other dementias are among the top 10 causes of death globally.