Transcranial alternating current stimulation is a safe, non-invasive therapy that modulates brain rhythms to treat disorders like depression and Alzheimer's. This review explains its mechanisms, summarizes clinical evidence, and highlights the future of personalized neuromodulation.

A web tool designed to spark reminiscence could help people with dementia and their caregivers feel more connected to each other and less impacted by feelings of pre-death grief, according to a clinical trial co-led by USC and Weill Cornell Medicine published in JAMA Network Open.

With features such as photo albums, autobiographical questions, and journaling prompts, the Living Memory Home for Dementia Care Pairs (LMH-4-DCP) website is a customizable virtual space that facilitates collaborative and interactive reminiscence therapy for both dementia patients and caregivers, said lead author Francesca Falzarano, assistant professor at the USC Leonard Davis School of Gerontology.

New research from Boston Children’s Hospital, published in Cell, finds that the brain’s resident immune cells, microglia, amass mutations in specific cancer-driving genes yet they don’t manifest as cancer. Instead, these mutations may help drive Alzheimer’s disease. These findings may provide insights into new Alzheimer’s disease diagnostics and treatments.