Published in the journal Brain, the study precisely describes how atrophy progresses in the medial temporal lobe and demonstrates the value of MRI as an early structural biomarker.

The study shows that atrophy in medial temporal lobe (MTL) regions begins 13 to 15 years before the first symptoms of Alzheimer’s disease in people with Down syndrome, opening a critical window for early detection and intervention.

The volume of the posterior hippocampus is confirmed as one of the most accurate structural biomarkers for identifying the symptomatic onset of Alzheimer’s, with diagnostic capacity comparable to cerebrospinal fluid analyses.

For the first time, a detailed chronological map of how MTL degeneration progresses in Down syndrome has been established, which could guide clinical trials and targeted therapies in very early stages of the disease.

BUFFALO, NY — June 12, 2025 — A new research paper was published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled “APOE genotype and biological age impact inter-omic associations related to bioenergetics.”

Older adults are quite aware of their financial abilities – and these abilities actually improve with age – that is, until dementia sets in, according to new research from Binghamton University, State University of New York.

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise.

A recent study by researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), has shown that a class of drugs, HDACi (histone deacetylase inhibitors), protects neurons and limits brain damage following stroke by altering the gene expression of microglia, the immune cells of the brain. HDACi are currently used or being tested as treatments for certain cancers and are also being researched for neurological conditions such as Alzheimer’s disease.