Alzheimer’s disease is the leading cause of dementia, yet its underlying mechanisms remain unclear. A new review published in the Chinese Medical Journal highlights how immune cells, including T and B cells, contribute to brain inflammation in Alzheimer’s. By pulling together findings from recent decades, the study suggests that targeting these immune responses could open the door to better treatments and diagnosis, offering hope against one of the most devastating neurological disorders worldwide.

The transformational grant will launch a new center led by Dr. Fanny Elahi to pursue treatments for understudied neurovascular diseases

Increased consumption of high-fat foods has been linked to cognitive decline. The underlying mechanisms, however, remain unclear. A new study by researchers from Chiba University, Japan, finds that a high-fat diet (HFD) impairs intermediate-term memory formation in Drosophila by decreasing autophagic activity. Further, HFD-induced memory deficits can be reversed by enhancing autophagic activity, opening avenues for the development of preventive treatments and autophagy-promoting lifestyle interventions to preserve cognitive function.

In a study led by Lund University and the Amsterdam University Medical Center, researchers used PET to analyse aggregates of tau pathology in more than 12,000 people from all over the world. The study – the largest ever of its kind – examines the connection between genetic predisposition, gender and age in relation to tau pathology in Alzheimer’s disease. The study is published in Nature Neuroscience.