Anti-neuroinflammatory natural products from isopod-related fungus now accessible via chemical synthesis
Peer-Reviewed Publication
In honor of Alzheimer's Awareness Month, we’re exploring the science and stories surrounding Alzheimer’s disease.
Updates every hour. Last Updated: 10-Sep-2025 00:11 ET (10-Sep-2025 04:11 GMT/UTC)
"Herpotrichone" is a natural substance that has been evaluated highly for its excellent ability to suppress inflammation in the brain and protect nerve cells, displaying significant potential to be developed as a therapeutic agent for neurodegenerative brain diseases such as Alzheimer's disease and Parkinson's disease. This substance could only be obtained in minute quantities from fungi that are symbiotic with isopods. However, KAIST researchers have succeeded in chemically synthesizing this rare natural product, thereby presenting the possibility for the development of next-generation drugs for neurodegenerative diseases.
With support from WoodNext Foundation, Dr. Jessica Bernard aims to develop treatments that have the potential to help those with Parkinson’s, Alzheimer’s and other neurodegenerative diseases.
New study shows that the way amyloid proteins—implicated in Alzheimer’s disease—assemble into fibrils can be significantly influenced by the spin orientation of electrons on magnetized surfaces. Depending on the direction of the magnetization and the chirality of the protein building blocks, the researchers observed major differences in the number, length, and structure of the resulting fibrils. These findings suggest that electron spin, through a mechanism known as Chiral-Induced Spin Selectivity (CISS), plays a direct role in protein self-assembly, pointing to a new and previously overlooked physical factor that could be harnessed to control or interfere with amyloid formation in neurodegenerative diseases.