Millions of people across the world suffer from Alzheimer’s disease, where sufferers experience memory impairment. Researchers from Tohoku University and the University of California, Irvine have recently identified dopamine dysfunction as a previously unrecognized mechanism underlying memory impairment. The discovery potentially opens the door to new therapeutic means that could reverse cognitive decline in Alzheimer’s patients across the globe.

People who carry the APOE2 version of the apolipoprotein E gene are more likely to live to advanced age and are partly protected against Alzheimer's disease, but scientists have struggled to explain why. A new study from the Buck Institute for Research on Aging, now published in Aging Cell, offers a mechanistic answer: APOE2 helps human neurons keep their DNA intact and resist becoming senescent, a damaged, dysfunctional state that accumulates with age and contributes to neurodegeneration.