Cell death discovery could lead to next-gen drugs for neurodegenerative conditions
Peer-Reviewed Publication
In honor of Alzheimer's Awareness Month, we’re exploring the science and stories surrounding Alzheimer’s disease.
Updates every hour. Last Updated: 28-Oct-2025 16:11 ET (28-Oct-2025 20:11 GMT/UTC)
In neurodegenerative diseases such as Alzheimer's or Parkinson's, proteins accumulate in the body's cells, fold incorrectly and clump together to form larger aggregates. Normally, cells are able to remove these aggregates themselves. However, if a certain enzyme is blocked, this clean-up process no longer works. This is shown in a new study by an international research team led by the University of Würzburg. The new findings provide a better understanding of the molecular basis of these processes.
Psychology literature has shown that curiosity tends to decline with age. Research from an international team of psychologists, including from UCLA, shows one type of curiosity can increase well into old age, contradicting prior research. Older adults who maintain curiosity and want to learn new things relevant to their interests may be able to offset or even prevent Alzheimer’s disease. Conversely, those who show muted curiosity and disinterest may be at risk for dementia.