Basophils, a type of white blood cell, promote recovery from acute respiratory distress syndrome (ARDS) in mice, according to researchers at Science Tokyo. In a mouse model of ARDS, basophils were found to release interleukin-4 (IL-4), which suppresses inflammatory neutrophils in the lungs during the recovery stage. The study suggests that targeting the basophil–IL-4–neutrophil pathway could offer a new therapeutic approach for ARDS, a condition with high mortality rates and no dedicated treatments.

Polyamines are natural molecules that promote healthy aging but are also linked to cancer progression, presenting a long-standing puzzle in biomedical research. In a recent study, researchers from Japan explored how polyamines affect cancer cells, uncovering a key interaction with protein eIF5A2. Their findings reveal that polyamines drive cancer growth by altering ribosomal gene expression, offering a potential target for selective cancer therapies and shedding light on the risks of polyamines.

Regulating the flow of protons across the chloroplast and modulating the activity of its CF_o-CF₁ adenosine triphosphate (ATP) synthase protein are key to protecting plants from excessive light energy absorbed during photosynthesis, report researchers from Institute of Science Tokyo, Japan. The research team generated a double mutant variety of Arabidopsis thaliana called dldg1hope2, lacking the DAY-LENGTH-DEPENDENT DELAYED-GREENING1 (DLDG1) protein, to assess the influence of DLDG1 on chloroplast CF_o-CF₁ ATP synthase activity.

Mitochondrial dysfunction has been implicated in bipolar disorder (BD). However, it remains unclear which brain region is affected. Now, researchers from Japan have investigated key brain regions involved in mood regulation (BD symptoms), such as the paraventricular thalamus and medial temporal regions; they found granulovacuolar degeneration in the paraventricular thalamus and verified the accumulation of tau proteins in medial temporal region. These findings pave the way for the development of new treatment strategies for BD.

A team of scientists at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS) has created a protein-based therapeutic tool  that could change the way we treat diseases caused by harmful or unnecessary cells. The new tool, published in Nature Biomedical Engineering, involves a synthetic protein called Crunch, short for Connector for Removal of Unwanted Cell Habitat. Crunch uses the body’s natural waste removal system to clear out specific target cells, offering hope for improved treatments for cancer, autoimmune diseases, and other diseases where harmful cells cause damage.

A metal-free organic liquid has been developed that phosphoresces at room temperature. Rapid phosphorescence endows the liquid with the highest phosphorescence efficiency in air among organic liquids. The new molecule has a 3-bromo-2-thienyl diketone backbone with attached dimethylocylsilyl (DMOS) groups. Attaching one DMOS group liquefies the backbone, whereas attaching two DMOS groups prevents molecular aggregation, which typically weakens phosphorescence. This new, flexible liquid can be applied to develop flexible electronic devices.

Cyclic ketene acetals (CKAs) contain carbon atoms and oxygen arranged in a ring-like structure and are ideal for designing degradable polymers. However, the complex reaction pathways and mechanistic factors involved during the polymerization process remain unclear. In a new study from Doshisha University, researchers have developed a simulation model and conducted in-depth nuclear magnetic resonance spectroscopic analyses to determine the critical factors that can influence radical ring-opening polymerization of CKAs.

This news article reports on a study revealing the importance of the proboscis monkey's large nose in vocal communication. Researchers used CT scans and computer simulations to demonstrate that the nose's shape modifies the resonant frequencies of calls, creating unique vocal signatures for individual monkeys. This discovery highlights the role of the nose in enhancing vocal identity and provides insights into the evolution of communication, not just in proboscis monkeys but potentially in other species as well. The collaboration between scientists and the Yokohama Zoo Zoorasia opens exciting new avenues for understanding the link between physical traits and social behaviors in the animal kingdom.