16-Apr-2025
Simulating protein structures involved in memory formation
Fujita Health UniversityPeer-Reviewed Publication
Complex protein interactions at synapses are essential for memory formation in our brains, but the mechanisms behind these processes remain poorly understood. Now, researchers from Japan have developed a computational model revealing new insights into the unique droplet-inside-droplet structures that memory-related proteins form at synapses. They discovered that the shape characteristics of a memory-related protein are crucial for the formation of these structures, which could shed light on the nature of various neurological disorders.
- Journal
- Cell Reports
- Funder
- Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Japan Society for the Promotion of Science, Kobayashi foundation, Kyoto University, Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Uehara Memorial Foundation, Naito Foundation, Research Foundation for Opto-Science and Technology, Novartis Foundation, Takeda Science Foundation, Human Frontier Science Program