A research team led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Faculty of Pharmaceutical Sciences at Toho University has revealed that ferulic acid (FA), a polyphenol abundant in rice bran, suppresses intestinal smooth muscle contractions by inhibiting voltage-dependent calcium channels. This finding may open new avenues for dietary-based strategies to manage intestinal motility disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).

A research team led by Professor Eiji Inoue from the Department of Biology, Faculty of Science, Toho University conducted a study on the Japanese weasel (Mustela itatsi). The Japanese weasel is an endemic species to Japan, but it was intentionally introduced to a number of non-native islands and its naturalization on some islands has resulted in severe negative consequences to the local ecosystems. 

A surgeon can excise breast cancer from the body, but even the most skilled scalpel may not be able to remove every cell — especially when the cells have spread from the original disease site elsewhere in the body. This proliferation and migration of breast cancer cells involves many still unknown molecular means, but researchers at Hiroshima University have elucidated at least one mechanism, involving protein receptors that bind to one another. With the discovery, they may have also uncovered how short chains of protein building blocks could serve as a novel anticancer drug.

Researchers from Fujita Health University have found that chronic hyponatremia (CHN), a condition of prolonged low blood sodium, induces anxiety-like behaviors in mice. CHN disrupts serotonin and dopamine levels and reduces extracellular signal-regulated kinase phosphorylation in the amygdala, a key brain region for emotion. These changes are reversible with sodium level correction. The findings suggest that CHN directly affects brain function and support early diagnosis and treatment to improve mental well-being in affected individuals.

Hyperthermia, a cancer treatment using controlled heat to kill tumor cells, shows promise but faces limitations due to some tumor cells' unexpected heat resistance. Researchers from Japan have now discovered that high cholesterol levels in cancer cell membranes act as a protective barrier, shielding against heat-induced membrane breakdown. When cholesterol was depleted using drugs, previously heat-resistant tumors became vulnerable to hyperthermia treatment, opening new possibilities for personalized cancer therapy targeting cholesterol levels to improve outcomes.

Reading a word involves complex interactions between spelling, meaning, and sound. Researchers from Japan and Canada explore the detailed role of orthographic-semantic consistency—how meaningfully related a word is to its spelling neighbors—in word recognition. By analyzing large datasets and conducting behavioral experiments, the team showed that morphologically-related addition neighbors (e.g., “CREAMY” for “CREAM”) facilitate recognition, while unrelated ones inhibit it. Their findings offer new insights into the cognitive architecture of word recognition. 

The explosive 2025 wildfire season in Central Canada reflects an increasing trend of large-scale burning driven by climate change. Using satellite and population data, we assessed the human consequences, revealing a significant international smoke event that exposed over 117 million people in the United States to heavy smoke on a single day. These fires, exacerbated by anomalously warm and dry conditions, underscore the urgent need for a paradigm shift to manage the cascading cross-border health and safety impacts of wildfires.

A new molecule that lets energy hop around quickly within its structure makes the upcycling of light more efficient and tunable. The Kobe University development lays out a design strategy for better solar power harnessing as well as medical and sensor applications.

A new study reveals striking international differences in how doctors approach the sensitive issue of tracheostomy invasive ventilation (TIV) for patients with amyotrophic lateral sclerosis (ALS). Cultural norms and healthcare systems appear to significantly influence physician attitudes and, consequently, patient choices regarding this life-sustaining treatment.

The Kaiser effect, which is known as a stress memory effect, predicts that seismic events occur only when the previous maximum stress is exceeded. However, the Kaiser effect has only been tested at room temperature in laboratories. Here, we performed deformation experiments on natural olivine at high pressures and high temperatures. We have successfully confirmed a stress memory effect in strongly deformed olivine at high pressures and high temperatures.