Role of specialized mucosal mast cells in IgE-mediated food allergy
Peer-Reviewed Publication
Updates every hour. Last Updated: 17-Jun-2025 19:10 ET (17-Jun-2025 23:10 GMT/UTC)
Food allergies can be life-threatening due to the rapid and exaggerated immune response. While mucosal mast cells (MMCs) are excessively proliferated during food allergies, the precise mechanisms that cause the overproduction of MMCs remain undiscovered. Now, a new study by scientists from Juntendo University, Japan, reveals the role of major histocompatibility complex class II (MHCII)-expressing mucosal mast cells in IgE-mediated food allergy.
In a study on public psychology with regard to the COVID-19 pandemic, researchers from Osaka University found no significant differences among regions of Japan regarding either risk perception or infection-prevention behaviors during the “state of emergency,” suggesting spillover effects between targeted and non-targeted regions. However, risk perception diminished after restrictions were lifted, and both risk perception and hygienic behaviors saw further reductions after the downgrading of the legal status of COVID-19 to that of a common seasonal flu.