Breaking the silence about men breaking bones
Reports and Proceedings
Updates every hour. Last Updated: 17-Dec-2025 06:12 ET (17-Dec-2025 11:12 GMT/UTC)
Women who experience severe bleeding after giving birth face elevated risks to their cardiovascular health that can persist for up to 15 years – a new analysis of data from over 9.7 million women across Europe, North America and Asia shows.
In a paper published in Molecular Biomedicine, researchers Xia Peng and Juan Du present a comprehensive review of lysine lactylation (Kla), a post-translational modification discovered in 2019. The study highlights Kla's role in linking cellular metabolism to epigenetic and signaling pathways by transferring a lactyl moiety to lysine residues, regulated by enzymes (writers/erasers) and metabolites like lactate, affecting both histone (e.g., H3K18la, H4K12la) and non-histone proteins (e.g., AARS1, ACSS2). In the review, the authors also elaborate on the mechanisms by which aberrant Kla triggers multiple disease processes. Meanwhile, the authors introduce the potential target sites of Kla.
In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The results, published June 24th in the open-access journal PLOS Biology, offer new hope for people with rare genetic conditions.
The transition from sprawling (reptile-like) to more upright (parasagittal) posture and locomotion was a transformative event in mammalian evolution. A study published June 24th in the open-access journal PLOS Biology by Dr. Robert Brocklehurst and Professor Stephanie Pierce at Harvard University, USA and colleagues suggests that parasagittal posture evolved via an indirect, dynamic, and radiating process.