A new study published in eLife shows that inhibition of p38γ/δ is a potential therapeutic strategy for the treatment of hypertrophic cardiomyopathy, but that this strategy has yet to be explored because of the lack of specific inhibitors for these p38 family members.
- Mineco-FEDER, American Heart Association, Lilly European Diabetes Research, Comunidad de Madrid IMMUNOTHERCAN-CM, Instituto Nacional de Corazón, Pulmón y Sangre, “la Caixa” Foundation, Fundación La Marató TV3, FP7 Marie Curie Programme, EFSD Rising Star prize
A research group led by Osaka Metropolitan University scientists and their Salvadoran colleagues implemented a survey over two years to assess vector infestation and the infection risk of the parasite Trypanosoma cruzi in triatomine bugs, the culprits responsible for Chagas disease, throughout El Salvador. Their findings showed the nationwide ubiquity of the principal insect vector and identified areas where these insects have high Trypanosoma cruzi infection rates. The results contribute to potential cost-effective vector control efforts that concentrate attention and resource allocation to highly infected areas in El Salvador.
- Infectious Diseases of Poverty
- Science and Technology Research Partnership for Sustainable Development, Japan Agency for Medical Research and Development, Japan International Cooperation Agency
A novel peptide augments the brain’s natural mechanism to help prevent seizures and protect neurons in research models of both Alzheimer’s and epilepsy, scientists report.
- JCI Insight
- NIH/National Institutes of Health
A deep dive into bird survey data has found that some of Australia’s favourite backyard visitors considered ‘common’ are actually on the decline as cities and suburbs opt for less greenery. The study, led by Griffith University and published in Biological Conservation, used citizen science data to examine the prevalence and diversity of bird species across Greater Brisbane, Greater Sydney, Greater Perth and Greater Melbourne. The team found that introduced species, historically prominent in Australian urban bird communities, were decreasing in prevalence in all four regions, while a small group of native urban exploiters were becoming more prevalent.
- Biological Conservation
Do pediatric kidney transplant patients have better long-term outcomes when their kidney comes from living, biologically unrelated donors compared to deceased donors? A new UC Davis Health study published in the journal Pediatric Transplantation finds that they do.
- Pediatric Transplantation
The Association for the Advancement of Blood and Biotherapies (AABB) has released clinical practice guidelines for the appropriate use of COVID-19 convalescent plasma (CCP) in hospital and outpatient settings. Based on two living systematic reviews of randomized controlled trials (RCTs), the guidelines provide five specific recommendations for treating patients with COVID-19 and suggest that CCP is most effective when transfused with high neutralizing titers to infected patients early after symptom onset. The guidelines are published in Annals of Internal Medicine.
- Annals of Internal Medicine