Acute kidney injury (AKI) remains a significant global health challenge, with high mortality rates and the potential for progression to chronic kidney disease. One promising avenue of intervention is targeting mitochondrial biogenesis (MB), a critical cellular process that promotes energy metabolism, stress resistance, and cell survival. By enhancing MB, it may be possible to restore mitochondrial function, alleviate oxidative stress, and improve renal recovery.

Emerging discoveries are reshaping the understanding of heart failure, highlighting the crucial role of gut microbiota in disease progression. The intricate relationship between gut health and cardiovascular function is becoming increasingly evident, revealing a bidirectional interaction known as the gut-heart axis. This dynamic connection suggests that imbalances in gut microbiota composition, known as gut dysbiosis, may contribute to cardiac dysfunction, inflammation, and metabolic disturbances that accelerate heart failure.