Infertility is a significant global health challenge impacting millions of families worldwide. Utilizing data from the Global Burden of Disease (GBD) 2021 study, a Chinese-led study examined global, regional, and national infertility prevalence and years lived with disability (YLDs) from 1990 to 2021. The study revealed a sustained increase in the global burden of infertility over the three decades, with a higher and more rapidly growing burden among women, alongside notable regional disparities. These findings could serve as a critical evidence base for developing evidence-based policies and resource allocation strategies to address the infertility burden.

The 2024 report on China’s gastroenterology and digestive endoscopy, based on national databases, highlights increased early cancer detection, optimized care for priority diseases, and enhanced endoscopy quality, with mixed cost trends for inflammatory bowel disease.

Scientists present a new approach that could empower the immune system to combat cancer cells and pave the way for new treatments for this deadly disease. The new insight stems from an extensive review of research on TIGIT, a protein known to inhibit the immune system’s ability to effectively attack cancer cells. Currently, a single drug can successfully neutralize TIGIT and enable immune cells to combat cancer in laboratory settings; however, clinical trials have been less successful.

Mass spectrometry (MS) is an analytical technique for molecular identification and characterization, with applications spanning various scientific disciplines. Despite its significance, MS faces challenges in widespread adoption due to cost constraints, instrument portability issues, and complex sample handling requirements. In recent years, 3D printing has emerged as a technology across industries due to its cost-effectiveness, customization capabilities, and rapid prototyping features. This review explores the integration of 3D printing with MS technology to overcome existing limitations and enhance biomedical analysis capabilities. We first categorize mainstream 3D printing methods and assess their potential in MS applications. We also discuss their roles in different MS categories such as liquid chromatography mass spectrometry (LCMS), gas chromatography mass spectrometry (GCMS), ambient ionization mass spectrometry (AIMS), and matrix-assisted laser desorption/ionization MS (MALDI MS) in biomedical research. Additionally, we highlight the current challenges and future research directions for advancing 3D printing-assisted mass spectrometry, emphasizing its role in enabling portable, cost-effective, and customized MS solutions for biomedical analysis.