About The Study: In this cohort study, fine particulate matter (PM2.5) and ozone exposure was independently associated with worse cardiac remodeling and function in patients with breast cancer treated with cardiotoxic therapy. These findings highlight the importance of modifying environmental exposures to mitigate cardiovascular disease risk.

About The Study: In this cohort study of patients in Norway discharged alive after critical injury, a 9-fold increased risk of suicide after 2 years was observed. These findings suggest that follow-up is warranted for possible psychological distress in this patient group.

About The Article: This JAMA Insights discusses post–intensive care syndrome (PICS), including how it is assessed and diagnosed as well as suggestions for treatment and prevention. A 9-minute video will be available with the article online at the embargo time that documents the story of an intensive care unit survivor who developed PICS. The video features interviews with clinicians and researchers to explore what PICS is, what causes it, and ways to help patients.

Recreational physical activity may be associated with breast tissue composition and biomarkers of stress in adolescent girls, according to a new study from Columbia University Mailman School of Public Health and the Herbert Irving Comprehensive Cancer Center (HICCC). The findings shed new light on how physical activity during adolescence—a critical period of breast development—may influence biological pathways related to future breast cancer risk.

Of all the types of breast cancer, triple negative breast cancer (TNBC) is the most aggressive and lacks specific therapies. TNBC also is more likely to metastasize, or travel through the blood stream to spread to other organs, which causes most of breast cancer-related deaths each year. Until now, tracking circulating tumor cells (CTC), a powerful indicator of cancer metastasis, has been challenging because there are very few markers that specifically identify these cells. In this study, researchers at Baylor College of Medicine report a procedure that led to the identification of four new proteins on the surface of live CTCs that specifically identify these cells both in mouse models and people with TNBC.