Alzheimer’s disease (AD) is a serious neurodegenerative disease largely affecting older adults. Apart from age, it also shows sex-based differences, with women being more at risk. However, the origin of these differences remains unknown. While bone morphogenetic proteins (BMPs) play an important role in adult neurogenesis, their role in AD remains elusive. To address this, researchers have investigated sex-based differences and role of BMP signaling in neurogenesis in AD mice models, uncovering novel therapeutic targets

Neurodegenerative diseases, traditionally viewed as driven by neuronal decline, are increasingly recognized to involve significant immune dysfunction within and outside the central nervous system (CNS). A new review by Professor Qiang Liu's team at Tianjin Medical University General Hospital synthesizes evidence that dynamic interactions between brain-resident and peripheral immune cells are crucial in diseases like Parkinson's disease (PD), offering fresh perspectives for developing treatments that can modify disease progression.