Alveolar bone defects can cause periodontal dehiscence, leading to exposure of dental roots, recession of gums, and increased tooth sensitivity. In a new study, researchers have evaluated the therapeutic potential of abaloparatide (ABL), a synthetic analog of human parathyroid hormone-related protein(PTHrP), in alleviating periodontal dehiscence. Utilizing rat models undergoing orthodontic tooth movement, they demonstrate that submucosal injection of ABL induces alveolar bone formation through a focal adhesion kinase(FAK)-driven mechanism.

A collaborative research team from Peking University has developed a novel method to enhance the tumor-targeting efficiency of γδ T cells through chemical engineering. By conjugating or gluing the cancer cell-targeting antibodies to γδ T cells via fast metabolic glycan labeling and click chemistry, the team achieved improved anti-tumor efficacy both in vitro and in vivo. This innovative approach holds significant promise for advancing adoptive cell therapy in cancer treatment.

A study conducted in mice by scientists from the Institut Pasteur and Inserm reveals that maternal consumption of dietary emulsifiers can have a negative impact on the gut microbiota of their offspring. These microbiota alterations are thought to significantly increase their risk of developing chronic inflammatory gut disorders and obesity in adulthood. The harmful transgenerational effects of maternal consumption of emulsifiers on the health of offspring highlight the need for additional research in humans on the impact of direct exposure to emulsifiers during early childhood. These findings were published in the journal Nature Communications.

Neoadjuvant therapies, or treatments given before surgery, are changing how doctors treat locally advanced colon cancer. In a recent review, researchers from the United States examined how pre-surgical chemotherapy and immunotherapy can shrink tumors, reduce recurrence, and improve surgical outcomes. They discussed clinical trials like FOxTROT and NICHE and highlighted the importance of using mismatch repair (MMR) status to guide treatment decisions and improve patient outcomes through personalized care strategies.

Migrant youth in Canada are less sexually active than peers, but contraception use is dropping, pointing to systemic barriers in sexual health access and underscoring the need for culturally relevant support.