Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation cycle of the Sir2 enzyme, reveal researchers from Science Tokyo. This finding reveals a new target for modulating Sir2, an enzyme that is essential for many biological processes, including aging, metabolic regulation, and cancer suppression. This finding could potentially lead to new therapeutic applications, including novel cancer treatments.

Space-occupying cyst (SOC), a fluid-filled sac that grows in a confined area of the body, is one of the major complications associated with brain tumor resection. Understanding the clinical features and management principles for such cysts can help patients to experience a favorable prognosis. In a recent Chinese Neurosurgical Journal Study, researchers analyzed and explored the potential characteristics and treatment strategies associated with this lesion.

A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated during infection with human coronavirus HCoV-229E and mediates the phosphorylation of the viral nucleocapsid (N) protein, an integral step in the virus cycle. These results aid in better understanding virus-host interactions and may open new approaches to exploring antiviral strategies in the long term. The team led by Dr. Yannick Brüggemann and Professor Eike Steinmann reports its findings in the journal npj Viruses from September 18, 2025.

According to “Global Cancer Statistics- 2022”, colorectal cancer (CRC) ranks third in incidence and second in cancer-related mortality. Given that approximately 50% of cases progress to metastasis and have an unfavorable prognostic rate, CRC represents a significant health and economic burden.

International students contribute to the academic and economic vitality of US higher education while facing exacerbated mental health challenges. Little is known about national trends in anxiety, depression, suicidal ideation and mental health service utilisation in this population. This study examined national trends in the prevalence of clinically significant anxiety, depression, suicidal ideation and service utilisation among international students in US higher education from 2015 to 2024.