In recent years, the regulatory role of the gut microbiota in the initiation and progression of colorectal cancer (CRC) has attracted growing attention. Among the key microbial contributors, Fusobacterium nucleatum (Fn) has been identified as a critical pathogenic factor in CRC. As an oral anaerobic commensal, Fn is rarely found in the lower gastrointestinal tract of healthy individuals. However, under pathological conditions, it can ectopically colonize the gastrointestinal tract. Once enriched in the colorectal environment, mounting evidence suggests that Fn is involved in multiple aspects of CRC pathogenesis, including initiation, progression, metastasis, and resistance to conventional therapies such as chemotherapy, radiotherapy, and immunotherapy. A recent review by Wei Wei and Diwei Zheng's team at the Institute of Process Engineering systematically outlines the pathogenic mechanisms of Fn in CRC and summarizes both current and emerging strategies for its therapeutic targeting. Furthermore, the authors propose potential approaches to overcome existing challenges in Fn modulation, aiming to facilitate more effective therapeutic interventions and improve clinical outcomes.

Football’s governing body FIFA should drop Coca-Cola as sponsors of the 2025 Club World Cup which begins this week, urge doctors in The BMJ today.

A newly published analysis reveals that individuals with severe depression who received electroconvulsive therapy (ECT) were 34% less likely to die by suicide compared to those treated with standard alternatives such as anti-depressant medication. This comprehensive meta-analysis is the first of its kind to demonstrate such a significant reduction in suicide risk linked to ECT. The findings also show that patients receiving ECT had 30% fewer deaths from any cause, suggesting broader health benefits beyond mental health.

In a new paper published in the journal Psychological Review, Cory Cobb, PhD, assistant professor in the Department of Health Behavior at the Texas A&M University School of Public Health, and colleagues from the University of Texas at Austin, proposed a cultural continuity hypothesis stating that humans are universally motivated to retain and preserve key parts of their cultures across time and space.

For the study, published in Safety and Health at Work, researchers explored how earned sick leave laws impact rates of reportable nonfatal illness or injury across major industry categories. They obtained annual state rates of occupational nonfatal illness or injury reports and earned sick leave policy data. They found that states that implemented earned sick leave prior to 2019 saw a marginally significant increase in the rates of illness and injury reporting across industries after these policies were introduced.