University of Delaware neuroscientists identified a previously unknown neural circuit in fruit flies that marks an early step in how the brain decides whether food is rewarding. The finding helps explain cravings and overeating and offers new clues to eating disorders and addiction.

E-cigarettes are attracting growing numbers of users, including teenagers, yet their health effects remain poorly understood. Researchers at Kyushu University found that e-cigarette vapor—regardless of nicotine content—released carcinogens, such as formaldehyde, and disrupted gut microbiome stability in zebrafish, reducing certain beneficial bacteria while increasing xenobiotic degradation-associated microbes. Exposed fish also showed impaired behavioral responses. The findings raise concerns about inadequately disclosed e-cigarette ingredients and highlight the need for greater transparency and evidence-based regulation.

PrECOG, LLC, today announced the publication of final results from the pivotal phase 3 PATINA study in the New England Journal of Medicine which evaluated whether adding palbociclib to anti-HER2 and endocrine therapy, following induction chemotherapy, could delay disease progression in patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–positive (HER2+) metastatic breast cancer. Results showed a median progression-free survival (PFS) of 44.3 months in the palbociclib arm, compared with 29.1 months in the control arm.

A research team at the Korea University College of Medicine has uncovered a genetic mechanism responsible for delayed tooth development and impaired mineralization.