Why do genetically identical cells respond differently to the same external stimuli, such as antibiotics? This long-standing mystery has been solved by KAIST and IBS mathematicians who have developed a new framework for analyzing cell responses to some stimuli. The team found that the cell-to-cell variability in antibiotic stress response increases as the effective length of the cell signaling pathway (i.e., the number of rate-limiting steps) increases. This finding could identify more effective chemotherapies to overcome the fractional killing of cancer cells caused by cell-to-cell variability.

Physicists know about the huge chasm between quantum physics and the theory of gravity. However, in recent decades, theoretical physics has provided some plausible conjecture to bridge this gap and to describe the behaviour of complex quantum many-body systems, for example black holes and wormholes in the universe. Now, a theory group at Freie Universität Berlin and HZB, together with Harvard University, USA, has proven a mathematical conjecture about the behaviour of complexity in such systems, increasing the viability of this bridge. The work is published in Nature Physics.

Researchers use computer simulations to show that extreme weather phenomena can be controlled and modified by making small adjustments to variables in the weather system. The study’s findings promise multiple future applications where weather events can be better controlled, including the effects of climate change. The study was published today in Nonlinear Processes of Geophysics.