Based on data from over 1000 regional studies combined with machine learning, researchers estimate that as many as 1.4 billion people live in areas with soil dangerously polluted by heavy metals like arsenic, cadmium, cobalt, chromium, copper, nickel, and lead. The study reveals a global risk, but also a previously unrecognized high-risk, metal-enriched zone in low-latitude Eurasia, in particular. The growth in demand for critical metals means toxic heavy metal pollution in soils is only likely to worsen. “We hope that the global soil pollution data presented in this report will serve as a scientific alert for policymakers and farmers to take immediate and necessary measures to better protect the world’s precious soil resources,” say the authors. Toxic heavy metal pollution in soil, originating from both natural sources and human activities, poses significant risks to ecosystems and human health. Once introduced into soils, such metals can persist over decades. These pollutants reduce crop yields, affect biodiversity, and jeopardize water quality as well as food safety through bioaccumulation in farm animals. However, while previous studies have shown that toxic metal pollution is ubiquitous in soils, its worldwide distribution remains poorly understood. To address this knowledge gap, Deyi Hou compiled data from 1,493 regional studies encompassing 796,084 soil samples to assess the global distribution of toxic metals in agricultural soils and to identify where concentrations exceed safety thresholds. Using machine learning and modeling approaches, Hou et al. estimate that 14–17% of cropland globally – roughly 242 million hectares – is contaminated by at least one toxic metal, with cadmium being the most widespread, especially in South and East Asia, parts of the Middle East, and Africa. Nickel, chromium, arsenic, and cobalt also exceeded thresholds in various regions, largely due to a mix of natural geological sources and human activities such as mining and industrialization. Moreover, findings revealed a transcontinental “metal-enriched corridor” stretching across low-latitude Eurasia, which likely reflects the cumulative effects of ancient mining, weathering of metal-rich bedrock, and limited leaching over time. By superimposing these data with global population distribution, Hou et al. estimate that 0.9 to 1.4 billion people live in high-risk areas.

A groundbreaking study published in the journal Current Neuropharmacology highlights a concerning potential link between Glucagon-like Peptide-1 (GLP1) receptor agonists—widely used in blockbuster drugs like Ozempic—and the risk of depression and suicidal ideation (SI). Using advanced pharmacogenomic computational analyses, the international team of 24 researchers revealed genetic pathways that may induce depressive phenotypes in users of GLP1 agonists, raising significant concerns about the safety of these medications for certain individuals.

A clinical trial conducted at Oregon Health & Science University’s neonatal intensive care unit has identified a new treatment protocol to improve lung growth and function among preterm infants. 

How should we prioritize patients waiting for kidney transplants? A new study could help policymakers analyze methods of matching donated kidneys and their recipients.